Astellas Pharma Gmbh

Juridical Foundation the Chemo-sero-therapeutic Research Institute

The Chemo-sero-therapeutic Research Institute

Katsunari Taguchi

Takanori Sasaki

Hiromu Sato

Makoto Ohori

Toshihiro Nakashima

Masaharu Torikai

Hirofumi Higuchi

Atsuo Yonezawa

Nobuchika Yamamoto

Hirotada Fujita

Fumihiko Sakai

Daisuke Ishikawa

The invention provides an anti-human IL-23R antibody having excellent activity and/or cross-reactivity compared to conventional IL-23R antibodies and methods of using the same for treating or preventing various diseases in which human IL-23R is involved in the pathogenesis of the diseases.

Anti-human IL-23 receptor antibody

[Problem] An object of the present invention is to provide an anti-human IL-23R antibody having excellent activity and/or cross-reactivity compared to conventional IL-23R antibodies, and means for using the antibody to prevent or treat various diseases such as ophthalmic disease, inflammatory bowel disease, or psoriasis in which human IL-23R is involved in pathogenesis. [Means for Solution] An anti-human IL-23R antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:10 or 14 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:6 or 18.

Anti-human IL-23 receptor antibody and encoding polynucleotides

The present invention provides a human anti-&#x3b1;9 integrin antibody or an antibody fragment which specifically recognize human &#x3b1;9 integrin and mouse &#x3b1;9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse &#x3b1;9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-&#x3b1;9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.

Human anti-&#x3b1;9 integrin antibody

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Tokyo, Japan

Katsunari Taguchi