Otsuka Pharmaceutical Factory, Inc.

Katsumi Uei

Keiichi Kawakami

Katsushi Watanabe

Teru Nakai

Tatsuya Ishii

Takashi Fujimoto

Yuki Hirata

Aya Bandou

The invention provides a reducing sugar-containing fat emulsion comprising an oil-in-water fat emulsion available upon emulsification of a fat with an emulsifier wherein a reducing sugar and at least one buffer substance selected from among organic acids with acid dissociation exponents in water within the range of 5.0-7.5 and their salts are concurrently contained in the water phase thereof, with the emulsion having been adjusted to pH 5.0-7.5; a reducing sugar-containing fat emulsion product which comprises a medicinal fluid containing a reducing sugar and a fat as sterilized with carbon dioxide gas dissolved therein and contained in a plastic infusion container, said plastic infusion container being accommodated together with a carbon dioxide gas absorber in a substantially oxygen-impermeable secondary container; and a method for their preparation and sterilization. The reducing sugar-containing fat emulsion is stable and of high quality, because it is inhibited against formation of free fatty acids, decomposition of the reducing sugar, and hence coloration.

Reducing sugar-containing fat emulsion and a method for its sterilization

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Naruto, Japan

Katsumi Uei