Ajinomoto Co., Ltd.

Canon Finetech Inc.

Canon Aptex

Toyo Soda Mfg. Co., Ltd.

Sagami Chem. Rsch. Cntr.

Katsumi Sugiyama

Tsutomu Harada

Tatsuya Fukushima

Masataka Naito

Masatoshi Ikkatai

Hitoshi Fujimoto

Toshihide Yukawa

Takefumi Tamura

Tsuyoshi Mikoshiba

Shinichi Kishimoto

Hideo Takeda

Hiroko Sato

Tadashi Takemoto

Toru Ikeda

Kiyotaka Oyama

Yuji Nonaka

Yoshihiko Kitahara

Satoji Takahashi

Masashige Kubo

Kazunari Nishimoto

Shinichi Iwasaki

Yuichi Watanabe

Masanao Ozaki

Takashi Yamashita

Keizo Matsuda

Yuzo Wada

Shigeru Inose

Emiko Shinohara

Kohei Ishikawa

Toshiyuki Ozawa

Nobuya Nagashima

Yoshinobu Uchida

Masaaki Iida

Hiroo Kageyama

Kiyo Adachi

Miyoji Dazai

Hideo Tazuke

A printer includes an ink jet head, a recovery unit, a moving unit, a conveying unit and a cover. The ink jet head performs printing on a printing medium and has an ink ejection port on an ejection port forming surface. The recovery unit is used for a recovery process for maintaining an ink ejection state of the ink jet head in a good condition. The recovery unit includes a cap for covering the ejection port forming surface, a wiping member for wiping the ejection port forming surface, and an absorbing member for receiving ink ejected from the ejection port of the ink jet head. The moving unit moves the recovery unit to a position where the recovery unit faces the ink jet head and to a position where the recovery unit does not face the ink jet head, the ejection forming surface of which is oriented toward the printing medium. The conveying unit conveys the printing medium to be printed by the ink jet head. The cover contains the ink jet head and the recovery unit. The cover is arranged to be opened so that a conveying path of the conveying unit appears and to be closed to cover the conveying path.

Recovering apparatus for recovering a status of an ink jet recording head

In a recovering apparatus for recovering ink ejecting ports forming a plane of an ink jet head, an ink absorbing member is disposed inward of a cap and proximate to the ink ejecting ports, facing the ink ejecting ports at a predetermined distance therefrom. Large ink droplets or water droplets adhering to the ink ejecting ports are then absorbed in the absorbing member. Thereafter, the plane of the ink jet heads with the ink ejecting ports is cleanly wiped by a wiping member, thereby preventing scattering of ink droplets or water droplets away from the ink ejecting ports. A trough is located adjacent to each head, and the recovering apparatus is disposed with respect to the trough so that a distance between the recovering apparatus and the ink jet head can be reduced, thereby permitting a compact arrangement of the recovering apparatus and the ink jet head.

A label printer performs recording on a roll label comprising a number of label sheets bonded in succession on a release sheet. The printer utilizes an ink jet method to attain a smaller size and to print information accurately. The printer comprises a conveyance section for conveying the label roll to an ink jet print head, an ink supply section for supplying ink to the head, and a recovery unit for making the head performance stable. A conveyance surface of the label roll is made substantially horizontal, with the ink jet print head and the recovery unit disposed above the surface and the ink supply section disposed underneath the surface.

Printer and printing method

A printing medium feeding apparatus comprises a conveying belt, on which a roll-shaped printing medium is placed with the lower surface of the roll being in contact therewith to unwind the outer periphery of the roll. With the arrangement, setup of the roll to the feeding apparatus is completed easily by only placing the roll onto the conveying belt, as compared with a construction in which the center of a roll is rotatably supported. It is also possible to omit or simplify a transmission mechanism such as a train of reduction gears that is necessary for the case of central driving. Further, it is also possible to feed a constant amount of length at a constant drive speed irrespective of radius of the roll.

Printing medium feeding apparatus using a specialized conveyor belt to

Mixture containing .alpha.-L-aspartyl-L-phenylalanine methyl ester and 3-benzyl-6-carboxymethyl-2,5-dioxopiperazine are brought into contact with hydrochloric acid in an aqueous solvent to precipitate .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride and 3-benzyl-6-carboxymethyl-2,5-dioxopiperazine, which are then separated from each other by classification.

Method of purifying .alpha.-L-aspartyl-L-phenylalanine methyl ester

A method of purifying .alpha.-L-aspartyl-L-phenylalanine methyl ester as a hydrochloride salt thereof which comprises:

Method of producing .alpha.-L-aspartyl-L-phenylalanine methyl ester

A method for crystallizing alpha-L-aspartyl-L-phenylalanine methyl ester (APM) is disclosed. The APM is crystallized from a C.sub.1 -C.sub.3 -alcohol/water solution (30-80:70-20 (v/v)). The ester crystallized by (i) concentrating the solution, (ii) cooling the solution, (iii) adjusting the water:alcohol ratio, or (iv) a combination thereof.

Method of separating alpha-L-aspartyl-L-phenylalanine methyl ester

A method for the production of N-carbobenzoxy-.alpha.-L-aspartyl-L-phenylalanine methyl ester characterized by the reaction of L-phenylalanine methyl ester with fine N-carbobenzoxy-L-aspartic anhydride crystals, is disclosed.

Method for production of N-protected-alpha-L-aspartyl-L-phenylalanine

A process for recovering .alpha.-L-aspartyl-L-phenylalanine methyl ester from a solution containing various methyl ester or demethylated derivatives of .alpha.-L-aspartyl-L-phenylalanine methyl ester and chloride ions is disclosed. This process uses a reverse osmosis membrane having a specific chloride inhibition rate to desalt and concentrate a solution containing a specified ratio of .delta.-L-aspartyl-L-phenylalanine methyl ester to its derivatives until a specific weight ratio of organic chloride ion to the sum of .alpha.-L-aspartyl-L-phenylalanine methyl ester and its derivatives is obtained. This desalted and concentrated solution is then contacted with an aqueous solvent containing methanol and hydrochloride acid to recover high yields of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride.

Method for recovering .alpha.-L-aspartyl-L-phenylalanine methyl ester

A process for producing .alpha.-L-aspartyl-L-phenylalanine methyl ester or its hydrohalide, which comprises subjecting 3-benzyl-6-carboxymethyl-2,5-diketopiperazine to partial hydrolysis with a strong acid in a solvent mixture of methanol and water.

Process for producing .alpha.-L-aspartyl-L-phenylalanine methyl ester or

A method for optical resolution of a DL-amino acid comprising reacting the DL-amino acid with an optically active N-acyl aspartic acid in a solvent or mixture of solvents, and separating the resulting two diasteromeric salts by way of the difference between their solubilities in the solvent or mixture of solvents. The difference in solubility may be enhanced by cooling, concentration, addition of a solubility-decreasing organic solvent, pH adjustment or salting out.

Amino acid complex and a method for optical resolution of a DL-amino acid

.alpha.-L-aspartyl-L-phenylalanine methyl ester II type crystals consisting of two types of crystals, II.sub.A and II.sub.B type, which interconvert from one to the other depending upon the equilibrium moisture content of the crystals, wherein one type of crystal, II.sub.a, exhibits X-ray diffraction peaks at angles of diffraction of at least 20.6.degree., 21.2.degree., 5.0.degree. and 11.1.degree., and the other type of crystal, II.sub.B, exhibits X-ray diffraction peaks at angles of diffraction of at least 15.2.degree., 11.1.degree., 19.6.degree. and 4.5.degree., as measured by X-ray diffractometer using CuK.sub..alpha. radiation and wherein the equilibrium moisture content of either of the crystals at a relative humidity of 78% is not higher than about 3%.

Dipeptide crystals, and process for their production

The invention provides a novel and efficient method for the elimination of protecting groups, e.g. benzyloxycarbonyl group, from a protected amino acid, peptide or derivative thereof having at least one functional group protected by a protecting group, e.g. a lower alkyl ester of N-benzyloxycarbonyl-.alpha.-L-aspartyl-L-phenylalanine by catalytic hydrogen reduction to produce free amino acid, peptide or derivative thereof. In contrast to the conventional procedures in which the reaction is carried out in a solvent dissolving both the starting compound and the product compound or a solvent dissolving the starting compound but not dissolving the product compound, the inventive method utilizes a binary two-phase reaction medium composed of water and an organic solvent not freely miscible with water such as toluene. The reaction takes place in the organic phase containing the starting compound dissolved and the catalyst dispersed therein whereas the reaction product which is water-soluble is smoothly and successively transferred into the aqueous phase so that advantages are obtained in the unexpectedly high yield of the product as well as in the easiness of handling the reaction mixture after completion of the reaction.

Method for reductive elimination of protecting groups

The reaction between L-aspartic acid and benzyloxycarbonyl chloride is carried out at a specific pH range, i.e., 12.0 to 13.5, whereby highly pure N-benzyloxycarbonyl-L-aspartic acid can be obtained in high yields, while both the by-production of N-benzyloxycarbonyl-.alpha.- or .beta.-L-aspartyl-L-aspartic acid and the decomposition of benzyloxycarbonyl chloride to benzyl alcohol are suppressed.

Method of producing N-benzyloxycarbonyl-L-aspartic acid

Hemi-alkali metal salts of 2-pyrrolidone-5-carboxylic acid, believed to have the formula: ##SPC1## Wherein Me is an alkali metal, is formed by reaction of 0.75 to 0.99 moles of an alkali metal hydroxide per mole of 2-pyrrolidone-5-carboxylic acid.

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Kawasaki, Japan

Katsumi Sugiyama