Eisai Company, Limited

Katsumi Onai

Sumio Watanabe

Kiyoshi Iwamoto

Kazuhide Ashizawa

James P McShane

Yasuo Ishibashi

Yasuyuki Asai

Ray Wood

The present invention provides pharmaceutical formulations suitable for intravenous injection comprising a lyophilized anti-ulcerative agent reconstituted in isotonic solutions suitable for intravenous administration, such as 5% dextrose or 0.9% sodium chloride. The solutions are brought to a pH of between about 9 and about 12, preferably between about pH 10 and 11, by a glycine-sodium hydroxide buffer. Such formulations are chemically and physically stable, and do not significantly change color, for at least between about 6 and about 12 hours at room temperature, and are stable to color change for from between about 24 and 48 hours if kept at 5&#xb0; C.

Pharmaceutical formulation comprising glycine as a stabilizer

The present invention provides a preparation for injection containing a lipid A analog and a process for preparing the same. A preparation for injection prepared by dissolving a lipid A analog or a pharmacologically acceptable salt thereof in an alkaline aqueous solution, at an elevated temperature if necessary, and then adding a buffer thereto, and a process for preparing the same.

Injections containing lipid a analogues and process for the preparation thereof

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Aichi, Japan

Katsumi Onai