Shionogi Company Limited

Glaxo Group Limited

Katsuki Yokoo

Toshiaki Aoki

Kenji Yamawaki

Jun Sato

Neil David Pearson

Yasuhiro Nishitani

Israil Pendrak

Xiangmin Liao

Masayuki Sano

Shinya Hisakawa

Hiroki Kusano

Reema K Thalji

Yutaka Yokota

Masatoshi Takeo

Mikito Asai

Reema Thalgi

The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

2 substituted cephem compounds

The invention relates to processes for the production of intermediates for preparing 2-alkyl cephem compounds useful as antimicrobial drugs. The invention provides a process which comprises oxidating a compound of the formula (I) or a salt thereof to give a compound of the formula (II) or a salt thereof wherein each symbol is as defined in the specification. 

Processes for production of intermediates for 2-alkyl cephem compounds

The present invention provides a novel compound which has a wide antimicrobial spectrum, and in particular exhibits potent antimicrobial activity against beta-lactamase producing Gram negative bacteria. Specifically, the present invention provides a compound of the formula (I): wherein each symbol is as defined in the specification, or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.

Cephem compound having catechol or pseudo-catechol structure

Growing community of inventors

Toyonaka, Japan

Katsuki Yokoo