Mochida Pharmaceutical Co., Ltd.

Katsuki Naitoh

Yoshitaka Hosaka

Motoyasu Honda

Kamon Shirakawa

Shoji Furusako

Tetsushi Kawahara

Tomokazu Matsusue

Hiroshi Takayama

Yumi Hotta

The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.

Anti-platelet membrane glycoprotein VI monoclonal antibody

The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof:

The present invention provides a convenient and highly sensitive method of determining sGPVI present in plasma; this is accomplished by establishing a plurality of mouse hybridomas that produce antibody against GPVI and combining the antibodies produced therefrom. Provided thereby are a novel platelet activation marker, a reagent and method for determining this novel platelet activation marker, and novel applications of this marker in, for example, the diagnosis of diseases associated with platelet activation/vascular endothelial injury.

Methods of detection GPVI

Growing community of inventors

Tokyo, Japan

Katsuki Naitoh