Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo Kabushiki Kaisha

Katsuichi Shuto

Hiroshi Kase

Shunji Ichikawa

Akio Ishii

Yoshimasa Oiji

Masayuki Teranishi

Kunikatsu Shirahata

Akira Karasawa

Kenji Ohmori

Hiroshi Sano

Hirofumi Nakano

Makoto Morimoto

Fumio Suzuki

Isao Kawamoto

Katsushige Gomi

Hiroyuki Obase

Haruki Takai

Shizuo Shiozaki

Shigeto Kitamura

Toru Yasuzawa

Takao Iida

Ikuo Matsukuma

Haruhiko Manabe

Toshiaki Kumazawa

Daisuke Machii

Iwao Kinoshita

Yasuo Onoda

Kenji Omori

Yoshinori Yamashita

Mitsuru Takahashi

Koji Yamada

Chikara Murakata

Masaji Kasai

Katsuhiko Ando

Kazuhiro Kubo

Junichi Shimada

Tetsuji Ohno

Ryo Okachi

Hiroshi Tanaka

Ichiro Miki

Yuzuru Matsuda

Eiji Hayakawa

Hiroshi Takizawa

Takeshi Kuroda

Etsuo Oshima

Nobuhiro Nakamizo

Kiyoshi Nakayama

Mitsunobu Hara

Tokuyuki Kuroda

Tadafumi Tamura

Kozo Asano

Nobuo Kosaka

Noriaki Hirayama

Hiroaki Hayashi

Hidee Ishii

Koji Suzuki

Yoshikazu Miwa

Tomoaki Masada

Hiromasa Kato

Yasuhiko Ueno

Hisayo Nomoto

Setsuya Sasho

Kazuyuki Iwahashi

Kazuko Hashizume

Takashi Deguchi

Masayuki Yamato

Mitsuru Terajima

Hirotake Naganuma

Kazuihiro Kubo

Shizuo Otaki

Nobuo Kasaka

A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis.

Triphenylmethane derivatives

Quinoline derivative having serotonin-3 receptor antagonizing activity

There are disclosed s-triazolo[3,4-i]purine derivatives represented by formula: ##STR1## wherein Y-Z represents ##STR2## R.sub.4 represents hydrogen, alkyl, substituted or unsubstituted aromatic heterocyclic group or substituted or unsubstituted aryl; and X.sup.2 represents oxygen, sulfur or NH; each of R.sup.1 and R.sup.2 independently represents hydrogen, alkyl, cycloalkyl, aralkyl or substituted or unsubstituted aryl; R.sup.3 represents alkyl, cycloalkyl, aralkyl or substituted or unsubstituted aryl; X.sup.1 represents oxygen or sulfur; and  represents a single bond or a double bond or pharmaceutically acceptable salts thereof.

s-Triazolo(3,4-I)purine derivatives

Novel dibenz[b,e]oxepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma and also employed in the treatment of inflammation.

Dibenz[b,e]oxepin derivative and pharmaceutical compositions thereof

A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits born absorption inhibiting effects and is useful as a medicament for treating osteoporosis.

A furan derivative and a pharmaceutically acceptable salt thereof having gastrointestinal enterokinetic activity which is expected to be used in a broad spectrum of diseases associated with gastrointestinal dyskinesia.

Furan derivatives useful for the treatment of gastro-intestinal disorders

A motilin preparation in the form of a rectal suppository containing motilin together with a pH controller capable of adjusting the pH value of the intrarectal fluid to 8.0 to 10.0, which is highly useful as a rectal suppository.

Rectal motilin preparation

Compounds having analgesic activity which have the formula ##STR1## wherein R.sub.1 -R.sub.6 represent hydrogen or a substituent and X and Y together represent inter alia as epoxyethylene, ethylene halohydrin, haloethylene or a --CH.dbd.CH-group.

UCY1003 derivatives

Novel substance UCY1003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities: ##STR1##

Novel substance UCY1003 and process for preparing the same

Disclosed are anti-dementia agents comprising an antiamnestically effective amount of a benzylpyridine derivative of the formula ##STR1## wherein R is an alkyl group. The invention also pertains to the treatment of dementia by administration of such anti-dementia agent.

Anti-dementia agent

Disclosed is a novel physiologically active substance, K-26, a process for preparation thereof and a pharmaceutical composition containing the same. The composition of matter, K-26, is useful as a hypotensive agent.

Novel physiologically active substances K-26, a process for preparation

Phosphorus-containing oligopeptide derivatives are prepared by synthetic methods. The compounds exhibit angiotensin converting enzyme-inhibiting action and are, therefore, useful as anti-hypertensive agents.

Phosphorus-containing peptide derivatives

A quinoline-N-oxide derivative represented by the formula: ##STR1## wherein X is hydroxy, lower alkoxy, lower alkylthio, unsubstituted or substituted aralkyloxy, or unsubstituted or substituted aralkylthio; Y is a hydrogen atom or halogen atom; R.sub.1 is alkylene or alkenylene having 3 to 15 carbon atom; Z is hydroxymethyl, lower alkoxymethyl, unsubstituted or substituted aryloxymethyl, tetrahydropyranyloxymethyl, tetrahydrofuranyloxymethyl, unsubstituted or substituted arylsulfonyloxymethyl, lower alkylthiomethyl, unsubstituted or substituted arylthiomethyl, lower alkylsulfinylmethyl, unsubstituted or substituted arylsulfinylmethyl, lower alkylsulfonylmethyl, unsubstituted or substituted arylsulfonylmethyl, aminomethyl, --CH.sub.2 NHR.sub.2 (wherein R.sub.2 is lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl), --CH.sub.2 NR.sub.3 R.sub.4 (wherein R.sub.3 and R.sub.4 are lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl), --CH.sub.2 N.sup.+ R.sub.5 R.sub.6 R.sub.7 (wherein R.sub.5, R.sub.6, and R.sub.7 are lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl, where the counterion is an anion of acid or a hydroxyl ion), --COR.sub.8 (wherein R.sub.8 is a hydrogen atom, lower alkyl or hydroxy), --CH(OR.sub.9).sub.2 (wherein R.sub.9 is lower alkyl), iminomethyl, hydroxyiminomethyl, or a halogen atom and its salts, can very strongly inhibit the lipoxygenase and considerably suppress production and release of its metabolites, and thus are useful as preventive and healing agents for the diseases caused by the lipoxygenase metabolites.

Quinoline-N-oxide derivative and pharmaceutical composition

A preventive and healing composition for diseases due to lipoxygenase metabolic products, which comprises an effective amount of a compound represented by the formula: ##STR1## wherein R is an alkyl group having 1 to 15 carbon atoms and at least one pharmaceutically acceptable carrier.

Preventive and healing composition for diseases due to lipoxygenase

A dibenz[b,e]oxepin compound having an antiallergic activity is represented by the following general formula: ##STR1## wherein R.sub.1 represents a cyano group, a 5-tetrazolyl group, a carbamoyl group or --CO.sub.2 R.sub.3 wherein R.sub.3 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms or a 1-(ethoxycarbonyloxy)ethyl group, and R.sub.2 represents a 4-alkylpiperazino group wherein the alkyl group has 1 to 5 carbon atoms, a 3-quinuclidinylamino group or --X--(CH.sub.2).sub.n --NR.sub.4 R.sub.5 wherein X represents --NH--, --S -- or --O--, R.sub.4 and R.sub.5 are same or different and each represents an alkyl group having 1 to 5 carbon atoms and n represents 2 or 3; and the pharmaceutically acceptable acid addition salts or metal salts thereof.

Dibenz[b,e]oxepin compounds

Growing community of inventors

Shizuoka, Japan

Katsuichi Shuto