Kowa Company Limited

Manac Incorporated

Katsuhiro Sakamoto

Junichi Sakata

Shinji Ina

Takahiro Yamazaki

Koji Ezaki

Provided is a method of manufacturing a high quality phosphonocrotonic acid derivative. The present invention is a method of manufacturing a compound represented by the following Formula (3) by reacting a compound represented by the following Formula (1) with a compound represented by the following Formula (2), which comprises a treatment process using an acid or base. [in the formula, Rrepresents a Clinear or branched alkyl group that may be substituted by a Caryl group, a Clinear or branched alkenyl group that may be substituted by a Caryl group, a Clinear or branched alkynyl group that may be substituted by a Caryl group, or a Caryl group, Rrepresents a hydrogen atom, or a Clinear or branched alkyl group that may be substituted by a Caryl group, Rrepresents a Clinear or branched alkyl group, a Caryl group, or a halogen atom, and X represents a halogen atom, and multiple Rs may be the same or different]. 

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Fukuyama, Japan

Katsuhiro Sakamoto