Nitto-denko Corporation

Sharp Kabushiki Kaisha Corporation

Toa Eiyo Ltd.

Mitsui Minings & Melting Co., Ltd.

Katsuhiro Okada

Yoshihiro Iwao

Kensuke Matsuoka

Masahiro Yoshida

Isao Ogasawara

Kunihiro Minami

Takehiko Kawamura

Katsuyuki Ookubo

Tetsuya Fujikawa

Hajime Imai

Satoshi Horiuchi

Junichi Morinaga

Masakatsu Tominaga

Ryohki Itoh

Hitoshi Akemi

Takashi Kinoshita

Toshiaki Fujihara

Katsuyuki Okubo

Masato Nishimura

Shuichiro Yuasa

Yoshihide Murakami

Isamu Yashima

Kazuhisa Ninomiya

Yoshihiro Asai

Kazunori Tanimoto

Kuniko Maeno

Katsushige Asada

Toshiyuki Yoshikawa

Kazumitsu Yamamoto

Yasuyuki Sasaki

Kenji Furumori

Atsushi Hamada

Akiko Sugioka

Osamu Sugimoto

Katsuhiro Mikumo

Tatsuji Saitoh

Seishi Suzuki

Shiro Satoda

Yasuaki Okada

Shunetsu Kikuchi

Makoto Higuchi

Yuko Yamamoto

Yuko Ueda

Noriyuki Takahashi

Akiyoshi Mikami

Kousuke Terada

Yuji Kawaharada

Hiroo Maeda

Masayasu Tanaka

Tokuji Nakanishi

Yukisama Sawada

Shuichiro c/o Toa Eiyo Ltd Yuasa

Kunihiro c/o Toa Eiyo Ltd Minami

The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 500,000-1,600,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.

Patch and patch preparation

In a liquid crystal display device () according to one aspect of the present invention, each of a first gate driver () supplying a gate signal to a first gate line () of a first display part () and a second gate driver () supplying a gate signal to a second gate line () of a second display part () are constituted to comprise a transistor formed on one surface of an array substrate ().

Display device

The present invention provides a patch package structure, which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, the first and second sheet materials being sealed together in peripheral parts thereof, and a patch disposed in the package, in which the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer; the second sheet material has been molded so as to have a protrudent part in at least a substantially central area thereof, the protrudent part having a planar outer shape larger than a planar outer shape of the release liner and having at least one recessed part; d is not smaller than T, in which d is the minimum gap distance between the inner surface of the first sheet material and the inner surface of the second sheet material at the recessed part and T is a thickness of the patch; and, at the boundary between the sealed part where the first and second sheet materials are sealed together and an unsealed part, the outer surface of the second sheet material rises at an obtuse angle.

Patch package structure

The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 1,700,000-6,500,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.

An active matrix substrate () is provided with first connecting wirings () connected to gate terminals () to which extraction wirings () are connected, second connecting wirings () connected to gate terminals () to which extraction wirings () are connected, bundled wirings (to) each composed of a mutually adjacent first connecting wiring and second connecting wiring bundled together, a first inspection wiring () capable of inputting an inspection signal to bundled wirings () that are not adjacent to each other among the bundled wirings, and a second inspection wiring () capable of inputting an inspection signal to bundled wirings () that are not adjacent to each other and not connected to the first inspection wiring () among the bundled wirings.

Active matrix substrate, display device, method for inspecting the active matrix substrate, and method for inspecting the display device

The problem of the present invention is to provide a patch preparation containing a drug (excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof), which is superior in both the skin permeability of a drug, and adhesiveness in the presence of water. A patch preparation containing a support and an adhesive layer on one surface of the support, wherein the adhesive layer contains a drug excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof, an acrylic polymer, lactic acid and magnesium aluminometasilicate.

Patch preparation

An adhesive pharmaceutical preparation which has a less irritation to the skin surface, keeps excellent stability of bisoprolol in the preparation, and allows continuous administration of a pharmacologically effective amount of bisoprolol into the living body, is provided. The adhesive preparationcomprises a support, an adhesive layerlaminated on one surface of the support. The adhesive layeris characterized by containing bisoprolol, polyisobutylene, tackifier, and an organic liquid ingredient compatible to polyisobutylene and tackifier. Thus, an adhesive pharmaceutical preparation which has a good adhesiveness with less irritation to the skin and which gives almost no pain at peel-off or removal from the skin surface with leaving almost no paste, can be provided. In addition, bisoprolol is very stably maintained in the preparation and a pharmacologically effective amount of bisoprolol can be administered continuously into the living body through the skin surface.

Adhesive pharmaceutical preparation containing bisoprolol

The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 &#x3bc;g/cm/hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 &#x3bc;g/cm/hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.

Percutaneous administration device of bisoprolol

An active matrix substrate () is provided with first connecting wirings () connected to gate terminals () to which extraction wirings () are connected, second connecting wirings () connected to gate terminals () to which extraction wirings () are connected, bundled wirings (to) each composed of a mutually adjacent first connecting wiring and second connecting wiring bunched together, a first inspection wiring () capable of inputting an inspection signal to bunched wirings () that are not adjacent to each other among the bundled wirings, and a second inspection wiring () capable of inputting an inspection signal to bundled wirings () that are not adjacent to each other and not connected to the first inspection wiring () among the bundled wirings.

Each of picture elements () has a plurality of alignment regions (RRRand R), in each of which liquid crystal molecules contained in a liquid crystal layer are aligned in a direction that is different from those in the others of the plurality of alignment regions. Each of a plurality of scanning signal lines () and a border region (Rand R) between corresponding adjacent ones of the plurality of alignment regions (RRRand R) at least partially overlap each other when viewed from above.

Liquid crystal display device

A manufacturing apparatus of a transdermal absorption preparation includes an adhesive sheet supplying part to feed out a band-like first adhesive sheet into a runway, wherein the adhesive sheet has at least an adhesive layer comprising an adhesive and a liquid component compatible with the adhesive, a drug liquid application part to apply a given amount of a drug liquid to an adhesive face, and a traveling section for impregnation which is set in the runway after the drug liquid application part, during which the adhesive sheet is run for a period necessary for the applied drug liquid to soak into the adhesive layer without contact of the drug liquid coated face of the adhesive layer with other members.

Manufacturing apparatus of transdermal absorption preparation

In the adhesive pharmaceutical preparation of the invention containing bisoprolol, a pressure-sensitive adhesive layer is laminated on one side of the backing. The pressure-sensitive adhesive layer contains a branched monoalcohol having from 12 to 28 carbon atoms, a free base of bisoprolol and a polyisobutylene pressure-sensitive adhesive. Accordingly, compatibility of the polyisobutylene pressure-sensitive adhesive with the free base of bisoprolol can be specifically increased. As a result, not only it becomes possible to increase blending amount of the free base of bisoprolol but also bleed of the free base of bisoprolol from the pressure-sensitive adhesive layer can be suppressed and, what is more, the pressure-sensitive adhesion characteristics sufficient from the practical point of view can be obtained.

The present invention relates to a patch package structure which includes: a package including a first sheet material and a second sheet material, the first and second sheet materials being sealed together in peripheral parts thereof; and a patch disposed in the package, the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having on a surface thereof a cut line supporting a peel-off of the release liner at the time of using the patch, the patch being disposed in the package so that the release liner faces the inner surface of the first sheet material, the first sheet material having a first region in which the inner surface of the first sheet material faces the cut line of the release liner, the first sheet material having in the first region a minimum first distance between the inner surface of the first sheet material and the surface of the release liner, and the inner surface of the first sheet material being spaced from the surface of the release liner at the minimum first distance in the first region.

A blister package comprises a blister and a cover sheet, and the blister has a groove formed in an outer edge section of the blister. The outer edge section of the blister includes an outer region and an inner region, the groove is formed on the inward side of the outer region, and the inner region is formed on the inward side of the groove. The peel strength between the outer region and the cover sheet is greater than the tear strength of the cover sheet, and the peel strength between the inner region and cover sheet is smaller than the tear strength of the cover sheet.

Blister package

A patch package structure which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, a peripheral area of the first sheet material having been sealed to a peripheral area of the second sheet material to constitute the package, and a patch disposed in the package; in which the patch includes a backing, a pressure-sensitive adhesive layer formed on at least one side of the backing, and a release liner which protects the pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having a weakening line for assisting a removal of the release liner; and in which the second sheet material has specific first protrudent part, second protrudent part, third protrudent part and elevated part in a central area thereof except the peripheral area thereof.

Growing community of inventors

Ibaraki, Japan

Katsuhiro Okada