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Fundacao De Amparo a Pesquisa Do Estado De Sao Paulo

Fundacao De Amparoa Pesquisa Do Estado De Sao Paulo-fapesp

Laboratorio Biosintetica Ltda.

Katsuhiro Konno

Yara Cury

Gisele Picolo

Renata Giorgi

Patricia Brigatte

Vanessa Gutierrez

Antônio Camargo

Tetsuo Yamane

Irina Kerkis

Alexandre Kerkis

Gandhi Rádis Baptista

Mirian Akemi Furuie Hayashi

Alvaro Rossan B P Da Silva

Lygia Da Veiga Pereira

Eduardo Brandt De Oliveira

Patrícia Brigatte

The present invention refers to analog compounds of peptides having the amino acid sequences SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 or SEQ ID NO: 4, including analgesic peptides derived from snakes of species such as; their uses in the treatment, diagnosis and prevention of painful conditions or mediated by opioid receptors, their pharmaceutical compositions and their methods of preparation and purification, including their uses in the identification of analgesic compounds.

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The present invention refers to uses of crotamine and compositions containing it, based on its characteristic of interaction with genetic material. Under submicromolar quantities, the polypeptide is no longer toxic, presenting the characteristics properties of cell penetration, transport of molecules to the surface, cytoplasm or cell nucleus and particularly, selective cell penetration. The invention also refers to compositions comprising a pharmaceutically effective concentration of crotamine and its use for the treatment of diseases and dysfunctions, based on its characteristics of interaction with genetic material, such as DNA and RNA, and cell selectivity. Further, the invention refers to a kit comprising crotamine as a reagent to: (i) transfect or carry molecules to the surface, cytoplasm or nucleus of the cell or (ii) identify and select actively proliferating cells in a homogeneous and/or mixed cell population, particularly the ones originated from the umbilical cord and/or bone marrow and others undifferentiated cells such as progenitors and stem cells from different sources of organism and cancer cells.

Methods, kits and compositions comprising crotamine

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São Paulo, Brazil

Katsuhiro Konno