The Kitasato Institute

The Kitasata Institute

Katsuhiro Komase

Tetsuo Nakayama

Chikara Aizawa

Noriko Suzuki

It was found that a mutation of an amino acid at a specific position in the P protein of a morbillivirus gives a temperature-sensitivity character to a virus. By introducing this mutation, a virus to which a temperature-sensitivity character has been introduced can be produced. According to this invention, attenuated viruses useful in the preparation of vaccines can be easily produced.

Method for producing temperature-sensitive morbillivirus

It was found that a mutation of an amino acid at a specific position in the F protein of ainduces a reduction in the cell-fusion ability. By introducing this mutation, a virus having a reduced cell-fusion ability can be produced. Thus, attenuated viruses useful in the preparation of vaccines can be easily produced.

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Tokyo, Japan

Katsuhiro Komase