Honda Giken Kogyo Kabushiki Kaisha

Mitsubishi Tanabe Pharma Corporation

Mitsubishi Pharma Corporation

Katsuhiko Itoh

Seigo Ishibuchi

Yoichi Naka

Hiroshi Sumichika

Masataka Eguchi

Mitsuharu Nakamura

Takao Kamahori

Yasushi Fujimoto

Mitsuru Saito

Takashi Shichinohe

Hideyuki Tawara

Yoshihiro Kimura

Ken Oike

Hiroshi c/o Mitsubishi Pharma Corp Sumichika

Seigo c/o Mitsubishi Pharma Corp Ishibuchi

The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic action wherein each symbol is as defined in the specification. The above-mentioned amide derivative, an optically active form thereof and a pharmaceutically acceptable salt thereof are promising as an agent for the treatment or prophylaxis of diseases or syndromes caused by inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis and pancreatitis and the like) due to activation of leukocytes caused by ischemia reperfusion, trauma, burn, surgical invasion and the like]. Moreover, they are useful as a therapeutic or prophylactic agent for the infectious diseases caused by bacteria and virus that invade via a C5a receptor.

Amide derivatives and medicinal use thereof

The present invention relates to a urea derivative of the formula (1) wherein each symbol is as described in the specification, a pharmaceutically acceptable salt thereof and pharmaceutical use thereof. The compound of the present invention has a C5a receptor antagonistic action and is useful as an agent for the prophylaxis or treatment of diseases or syndromes due to inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis, pancreatitis and the like) due to activation of leukocytes caused by ischemia, trauma, burn, surgical invasion and the like]. In addition, it is useful as an agent for the prophylaxis or treatment of infectious diseases caused by bacteria or virus that invades via a C5a receptor.

3-substituted urea derivatives and medicinal use thereof

A relief valve having a cylindrical case with one side thereof communicated with a fluid-pressure source, a relief piston accommodated in the cylindrical case and slidable therein, a return spring for pressing the relief piston against the fluid-pressure source, a damper chamber provided on a rear-surface side of the relief piston, said damper chamber communicated with the fluid-pressure source through an orifice of the relief piston and used for displaying a buffer action against an operation of the relief piston, and a relief hole bored through a wall of the cylindrical case, the relief hole communicated with the fluid-pressure source when the relief piston retreats due to an increase in pressure generated by the fluid-pressure source.

Relief valve

An overhead valve type internal combustion engine having a breather chamber without increasing the size of the internal combustion engine by taking advantage of a space that is already formed. An overhead valve type internal combustion engine includes a cylinder bore formed in a cylinder, a freely rotatable cam shaft located in a cylinder head, and also located to the side of the cylinder bore viewed from a direction of a centerline of the cylinder, a chain chamber, located to the side of the cylinder bore, for housing a chain for rotationally driving the cam shaft, and a breather chamber located so as to be below the cam shaft and parallel to the cylinder bore on one side of the chain chamber.

Overhead valve type internal combustion engine

A water pump for circulating the cooling water of an internal combustion engine, facilitates the formation of the water passage connecting the water pump to the cooling water passage in the cylinder block and can reduce manufacturing costs thereof. A water pump for circulating the cooling water of an internal combustion engine is connected to one end of a cam shaft for a valve system arranged in a cylinder head and is driven by the cam shaft. A delivery port of the water pump is extended near to a cooling water supply port formed in the side wall of a cylinder block and is connected to a cooling water passage in the cylinder block. The delivery poll of the water pump is extended to a position directly opposite to the cooling water supply port, and is connected to the cooling water supply port with a connection pipe. A mounting structure of a camshaft is capable of applying high speed rotation by shortening a length of push rods and also capable of facilitating maintenance such as replacement of cams. In an overhead valve type internal combustion engine, a camshaft is located and mounted in space surrounded by an upper portion of a cylinder and cylinder head.

Water pump for circulating cooling water in an internal combustion engine and camshaft mounting structure therefor

Growing community of inventors

Saitama, Japan

Katsuhiko Itoh