Hisamitsu Pharmaceutical Company, Inc.

Juridical Foundation the Chemo-sero-therapeutic Research Institute

Katsuhiko Akiyama

Takeshi Goto

Takashi Shimada

Hiroaki Maeda

Chikateru Nozaki

Masaki Hirashima

Shuji Sato

Iwao Nozawa

Hidekazu Kuma

Yosuke Suzuki

Osamu Iijima

Norio Matsukura

Katsuyuki Hamada

Takeshi Naruse

Fumio Fukai

Kazuhiro Yuda

Masaaki Ueki

Wataru Hattori

A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.

Peptide having cytotoxicity inhibitory activity and method of screening these peptide having cytotoxicity inhibitory activity

Gene expression base sequences for therapeutic use and drugs for gene therapy

Physiologically active peptides

Recombinant human immunodeficiency virus producing cell lines

A therapy for a disease, e.g., gastric cancer, comprising endoscopic local administration of a vector having a gene for treatment or cells producing the vector to a lesion to transduce the gene into target cells. The direct in vivo transduction of a gene for treatment into the affected site is expected to produce therapeutic effects specific on the lesion. Since the gene is introduced also into lymph nodes which may have developed a metastatic lesion, both the primary lesion and the metastatic lesion in the surrounding lymph nodes can be treated simultaneously.

Endoscopic administration of an HSV-tk gene to treat digestive organ

Liposome composition

Growing community of inventors

Tsukuba, Japan

Katsuhiko Akiyama