Nippon Shinyaku Company, Ltd.

Other

Katsuhide Saito

Hiroshi Enomoto

Hiromu Murai

Katsuya Ohata

Shoichi Chokai

Takayuki Ozaki

Yoshiaki Yoshikuni

Koji Kitaguchi

Yukio Fujita

Kenji Sempuku

Kohei Kura

Tamiki Mori

Yasuo Yasutomi

Mitsuhiro Machara

Mitsuhiro Maehara

A series of new 4,6-disubstituted 2-morpholinone derivatives were prepared either by a reaction of corresponding epoxide derivatives with phenylglycine derivatives or by the reaction of isopropanol derivatives with carboxylic acid derivatives. The new morpholinone derivatives are useful for the prevention or the treatment of arteriosclerosis.

Morpholinone derivatives and method of use

A process for the preparation of amide derivatives of abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid which comprises reacting abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid or a reactive derivative thereof with an amine of the following formula:

Abietamide derivatives, their production and use

New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.

Substituted N-(carboxymethyl)-3-aminopropan-2-ol derivatives

New carboxylic acid derivatives are proposed for use as agents in the treatment of prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.

Process for the preparation of abietanilides which comprises reacting abietic acid, dihydroabietic acid, tetrahydroabietic acid or a reactive derivative thereof with aniline and the products thereby produced, compositions containing the same for reducing blood serum cholesterol and method of use of such compositions.

Abietanilides, their production and use

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Kyoto, Japan

Katsuhide Saito