Meiji Seika Kaisha, Ltd.

Other

Bayer Aktiengesellschaft

Sakai Engineering Co., Ltd.

Katsuharu Iinuma

Yasushi Murai

Osamu Sakanaka

Tatsuo Watanabe

Masamichi Sukegawa

Masahiro Onodera

Kiyoshi Yasui

Peter Jeschke

Norbert Mencke

Achim Harder

Gerhard Bonse

Ken Nishihata

Yumiko Okada

Shinjiro Sumi

Yuichi Yamamoto

Toshio Yoneta

Toyomi Sato

Makoto Ohyama

Shouhei Yasuda

Katsufumi Sebata

Takashi Tsuruoka

Seiji Shibahara

Masao Koyama

Fumiya Hirano

Winfried Etzel

Takayoshi Tamura

Takeshi Teraoka

Rainer Zocher

Horst Kleinkauf

Masayuki Takagi

Gerhard Thielking

Masaaki Takahashi

Makoto Taniguchi

Kimiaki Yasuda

Tadaaki Okada

Hidehi Takebe

Haruki Mikoshiba

Hitoshi Yamada

Maki Matsumoto

Koichi Mitomo

Kikuko Kuzuhara

Maki Ohishi

Matsuko Katayama

Kouichi Miyamoto

Hiroyuki Iwasawa

Disclosed are novel compounds useful for prevention or control of diseases derived from fungi, a process for producing the same, and novel antifungal agents using the novel compounds. The compounds useful for prevention and treatment of diseases derived from fungi according to the present invention include novel compounds represented by formula (I). The compounds represented by formula (I) have potent antifungal activity against diseases derived from fungi, and do not have phytotoxicity to mammals and agricultural and garden plants, from which diseases should be eliminated, and, even when applied to agricultural and garden plants, have high photostability. wherein

Antifungal compound and process for producing the same

Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren pivoxil substance with a water soluble high-molecular additive. These compositions can be produced by dissolving crystalline Cefditoren pivoxil substance and the water-soluble high-molecular additive in an aqueous solution of an acid, then neutralizing the resultant solution, to co-precipitate the product, and drying the thus precipitated product, followed by recovering the product in the form of the above-mentioned particles.

Composition comprising a crystallographically stable, amorphous cephalosporin and processes for the preparation thereof

A crystalline substance of Cefditoren pivoxyl is provided which has a high purity and enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving an amorphous form of Cefditoren pivoxyl in an anhydrous, first organic solvent capable of dissolving said amorphous form well therein, and steps of replacing the first organic solvent component of the resulting solution by an anhydrous alkanol of 1 to 5 carbon atoms as a second organic solvent, in such a manner that the firstly prepared solution of Cefditoren pivoxyl in the first organic solvent is mixed with a volume of the alkanol and then is concentrated below 15&deg; C. under reduced pressure, and so on. Thereby, the process proceeds so as to produce a solution containing 50 mg/ml to 250 mg/ml of Cefditoren pivoxyl dissolved in the alkanol alone. From the latter solution, crystals of Cefditoren pivoxyl are induced to deposit by addition of water at a temperature of 0-10&deg; C. The resulting admixture of the concentrated solution of Cefditoren pivoxyl in alkanol with added water and the deposited Cefditoren pivoxyl is then agitated 10&deg; C. or below, to effect a complete crystallization of Cefditoren pivoxyl.

Crystalline substance of cefditoren pivoxyl and the production of the same

Crystallographically stable amorphous cephalosporin compositions and process for producing the same

Novel derivatives of PF1022 substance, which are cyclodepsipeptides represented by the general formula (I) shown below or their salts are useful as anthelmintic agent for prevention or treatment of parasitic infections.

Derivatives of cyclodepsipeptide PF1022 substance

As a novel substance is provided such a new, crystalline substance of Cefditoren povoxyl which has a high purity and an enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving amorphous substance of Cefditoren pivoxyl in an anhydrous, first organic solvent capable of dissolving said amorphous substance well therein, and steps of replacing the first organic solvent component of the resulting solution by an anhydrous alkanol of 1 to 5 carbon atoms as a second organic solvent, in such a manner that the firstly prepared solution of Cefditoren pivoxyl in the first organic solvent is mixed with a volume of the alkanol and then is concentrated below 15&deg; C. under reduced pressure, and so on. Thereby, the process proceeds so as to produce a solution containing 50 mg/ml to 250 mg/ml of Cefditoren pivoxyl dissolved in the alkanol alone. From the latter solution, crystals of Cefditoren pivoxyl are induced to deposit by addition of water at a temperature of 0-10&deg; C. The resulting admixture of the concentrated solution of Cefditoren pivoxyl in alkanol with added water and the deposited Cefditoren pivoxyl is then agitated 10&deg; C. or below, to effect a complete crystallization of Cefditoren pivoxyl.

There can be produced, at a high selectivity and in a high yield, the Z-isomer of a 7-N-unsubstituted or substituted-amino-3-&lsqb;2-(4-substituted or unsubstituted-thiazol-5-yl) vinyl&rsqb;-3-cephem-4-carboxylic acid or an ester thereof having the general formula (IV)

Process for the selective preparation of Z-isomers of 3-2(substituted vinyl)cephalosporins

The present invention relates to cyclic thiodepsipeptides, in particular 18 to 24-membered cyclothiodepsipeptides, their endoparasitical compositions, and methods of making and using the same.

Thiodepsipeptides for combating endoparasites and a method for producing the same

Process for the preparation of substituted aryl lactic acid containing

Derivatives of cyclodepsipeptide PF 1022

New compounds are disclosed having the general formulas (1) and (2): ##STR1## Also described is a process for preparing the compounds of formulas (1) and (2). Further described is a process for preparing a cephalosporin derivative having formula (5): ##STR2## by converting the compound of formula (1) to the compound of formula (2) and then converting the compound of formula (2) to the compound of formula (5).

Azetidinone derivatives and method for producing azetidinone and

Method for producing azetidinone and cephalosporin derivatives

An antibacterial and deodorant processing agent for the sanitary processing, in particular, for the sanitary processing of a fiber material having a hydrophobic surface, which comprises a derivative of an aminoglycoside antibiotic, and a method for the antibacterial and deodorant processing of a fiber material having a hydrophobic surface with the use of said antibacterial and deodorant processing agent.

Antibacterial and deodorant processing agent and processing method using

Sodium 7.beta.-(2D-2-amino-2-carboxyethylthioacetamido)-7.alpha.-methoxy-3-(1-met hyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate heptahydrate and a method of obtaining it from the corresponding carboxylate.

Sodium

Growing community of inventors

Odawara, Japan

Katsuharu Iinuma