Ajinomoto Co., Ltd.

Seiko Instruments Inc

Katsuaki Sato

Hitoshi Enei

Yoshio Hirose

Hiroyuki Kojima

Hiroshi Matsui

Tsuyoshi Nakamatsu

Masakazu Sugimoto

Akiko Tanaka

Yasuyuki Mitsuoka

Hisao Ito

Yoshihiro Usuda

Kazuhiko Matsui

Shigeru Nakamori

Kunio Nakajima

Konosuke Sano

Takashi Tanaka

Yukiko Ono

Morikatsu Ishii

Yasuo Anzai

A nucleic acid substance is efficiently produced by cultivating a microorganism whose repressor protein for purine operon does not function in a normal manner, preferably a strain whose gene encoding the repressor protein on a chromosome (purR) is disrupted, in a culture medium so that the nucleic acid substance should accumulate in the culture medium, and collecting the substance from the culture medium.

Method for producing nucleic acid substances

An optical fiber probe which has a minute opening on the top of a sharpened tip is allowed to get close to a sample, and the probe is moved by a piezo actuator along x- and y-axis directions so that a minute spot beam emanating from the minute opening can scan over the sample. For circular polarization modulation to be incorporated in the process, a beam, before it is incident on the optical fiber probe, is given an optical delay changing at a frequency of p (Hz) by means of a piezo-optical modulator. A minute spot beam emanating from the minute opening passes through the sample to be received after the passage through an analyzer by a light receiving element. The output from the light receiving element is fed to a lock-in amplifier, p- and 2p-components are separated through lock-in rectification, and they are rendered images by a controller.

Scanning near field optical microscope based on the use of polarized

A process for producing L-leucine, which includes incubating an L-leucine-productive microorganism belonging to the genus Corynebacterium, Escherichia, Brevibacterium, or Microbacterium in a culture medium and reacting the resulting cells with saccharides and acetic acid or its salt to form and accumulate L-leucine in the reaction solution. The process improves the amount of L-leucine accumulated and decreases formation of amino acid byproducts.

Process for producing L-leucine

A plasmid having a temperature-sensitive replication origin which has the following properties:

Temperature-sensitive plasmid

Temperature sensitive plasmid

The present invention relates to a process for producing an aromatic amino acid which comprises culturing a Coryneform bacterium carrying a recombinant DNA constructed by connecting (1) a gene capable of being expressed in a Coryneform bacterial cell and coding for 3-deoxy-D-arabino-heptulonic acid-7-phosphate synthetase with (2) a plasmid vector capable of propagating in a Coryneform bacterial cell.

Coryneform bacteria carrying recombinant DNA and a process for producing

Method for producing guanosine by culturing a guanosine-producing mutant of the genus Bacillus which requires adenine for growth, and is resistant to at least one sulfa drug.

Method of producing guanosine by fermentation

Mutant strains of Bacillus subtilis which require adenine for growth and are resistant to at least one sulfa drug produce inosine in culture medium.

Method for producing inosine by fermentation

Production of guanosine by fermentation with a Bacillus mutant requiring adenine for growth and resistant to psicofuranine or decoyinine.

Growing community of inventors

Kawasaki, Japan

Katsuaki Sato