Evonik Degussa Gmbh

Cargill Inc.

Katrin Grammann

Thomas Haas

Steffen Schaffer

Hans H Liao

Eileen Spindler

Wendy Kathleen Ribble

Volker Sieber

Tanya Lipscomb

Liv Reinecke

Jan Wolter

Catherine B Poor

Ronald J Evans

Harald Haeger

Arne Skerra

Jan Christoph Pfeffer

Andreas Karau

Thorsten Eggert

Olivier Zehnacker

Harald Häger

Andreas Schmid

Lars Mathias Blank

Peter Welters

Kai Doderer

Claudia Rollmann

Brittany Robinson

Brittany Prather

Bruno Buehler

Guido Jach

Jasmin Corthals

Alexandra Lerchner

Bruno Bühler

Dave A Hogsett

Andrea Weckbecker

David A Hogsett

Katrin Schullehner

Jürgen Haberland

Thomas Hüller

Broder Ruehmann

Andreas Mueller

Christian Rausch

Bernd Lalla

Broder Rühmann

Andreas MÜLLER

Gerlind Grimberg

Alexander Mohr

Manuel Holtkamp

Maik Olfert

Eileen C Spindler

Tanya Warnecke Lipscomb

Brittany L Prather

Nicole Potgrave

A microbial cell is used for producing at least one fatty acid ester, wherein the cell is genetically modified to contain (i) at least one first genetic mutation that enables the cell to produce at least one fatty acid and/or acyl coenzyme A (CoA) thereof by increased enzymatic activity in the cell relative to the wild type cell of malonyl-CoA dependent and malonyl-ACP independent fatty acyl-CoA metabolic pathway, wherein the fatty acid contains at least 5 carbon atoms; and (ii) a second genetic mutation that increases the activity of at least one wax ester synthase in the cell relative to the wild type cell and the wax ester synthase has sequence identity of at least 50% to a polypeptide of SEQ ID NO: 1-8 and combinations thereof or to a functional fragment of any of the polypeptides for catalyzing the conversion of fatty acid and/or acyl coenzyme A thereof to the fatty acid ester.

Production of fatty acids esters

The present invention relates to a cell, which has been genetically modified relative to its wild type, so that in comparison with its wild type it is able to produce more &#x3c9;-aminocarboxylic acids, more &#x3c9;-aminocarboxylic acid esters or more lactams derived from &#x3c9;-aminocarboxylic acids, starting from carboxylic acids or carboxylic acid esters. Furthermore, the present invention relates to a method for the production of a genetically modified cell, the cells obtainable by this method, a method for the production of &#x3c9;-aminocarboxylic acids, of &#x3c9;-aminocarboxylic acid esters or of lactams derived from &#x3c9;-aminocarboxylic acids, the &#x3c9;-aminocarboxylic acids, &#x3c9;-aminocarboxylic acid esters or lactams derived from &#x3c9;-aminocarboxylic acids obtainable by this method, a method for the production of polyamides based on &#x3c9;-aminocarboxylic acids or based on lactams and the polyamides obtainable by this method.

&#x3c9;-Aminocarboxylic acids, &#x3c9;-aminocarboxylic acid esters, or recombinant cells which produce lactams thereof

The invention relates to a method for the amination of at least one keto group in a multicyclic ring system comprising at least one keto group into an amino group, using at least one enzyme E having transaminase activity.

Method for producing multicyclical ring systems carrying amino groups

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Oer-Erkenschwick, Germany

Katrin Grammann