University of Texas System

Katja Michael

Igor Almeida

Rosa Maldonado

Nathaniel Schocker

Thomas Boland

Binata Joddar

Philip T Baily

Alfredo Ornelas Sanchez

Eva Adriana Iniguez

Susana Portillo

Javier Hernandez Ortega

Chunqlang Li

Hector P Del Castillo

Irodiel Vinales Lozano

Crosslinkers of an amide or thiocarbamate of 7-nitroindoline were prepared with at least two attached reactive groups for crosslinking capability. The photo-cleavability of the invented crosslinkers is based on the known photolysis behavior of N-acyl-7-nitroindolines, and the photolysis behavior of amides and thiocarbamates of 7-nitroindolines. These crosslinkers enable crosslinking of biopolymers, which can be reversed by illumination with light.

Photocleavable nitroindoline-based crosslinkers

Certain embodiments are directed to an immunogenic composition comprising an immunogenic glycoconjugate comprising a glycan having the chemical formula of galactopyranose (Galp)-&#x3b1;(1,2)-R, Galp-&#x3b1;(1,3)-R, Galp-&#x3b1;(1,4)-R, or Galp-&#x3b1;(1,6)-R, wherein in R is any monosaccharide, oligosaccharide, or polysaccharide, coupled to a carrier peptide or protein. Certain aspects described herein are directed to compounds and therapies for treatinginfections. In certain aspects, the glycoconjugates as described herein, are incorporated into pharmaceutical compositions or vaccines

Glycoconjugate vaccine for

Certain embodiments are directed to method for synthesizing and using glycoconjugates based on the immunodominant epitope Gal&#x3b1;(1,3)Gal&#x3b2;(1,4)GlcNAc&#x3b1; (Gal&#x3b1;3LN&#x3b1;).

Glycoconjugates and methods for their use

Certain embodiments are directed to method for synthesizing and using glycoconjugates on the immunodominant epitope Gal&#x3b1;(1,3)Gal&#x3b2;(3(1,4)GlcNAc&#x3b1; (Gal&#x3b1;3LN&#x3b1;).

Growing community of inventors

El Paso, TX, United States of America

Katja Michael