The General Hospital Corporation

Tufts Medical Center, Inc.

Katia Georgopoulos

Bruce A Morgan

Richard A Etten

Ila Joshi

Clair Kelley

Methods for the diagnosis and treatment of B cell Acute Lymphoblastic Leukemia (B-ALL), based in part on the detection and/or inhibition of Focal Adhesion Kinase (FAK), e.g., phosphorylated FAK (pFAK).

Methods of diagnosing and treating B cell acute lymphoblastic leukemia

Provided herein are (a) Aiolos gene, Aiolos polypeptides, Aiolos homodimers, Aiolos/Ikaros heterodimers and methods of using Aiolos nucleic acids and polypeptides; (b) Helios gene, Helios polypeptides, Helios homodimers, Helios/Ikaros heterodimers, Helios/Aiolos heterodimers, and methods of using Helios nucleic acids and polypeptides; (c) Daedalos nucleic acids, Daedalos polypeptides, and other related molecules and methods of making and using the same; and (d) Ikaros regulatory elements and uses thereof.

Aiolos, Helios, Daedalos and Ikaros: genes, polypeptides, regulatory elements and uses thereof

The invention features an Aiolos protein, and nucleic acid sequence encoding such protein. The invention also features methods of making and using an Aiolos protein, and methods of obtaining an antibody from an animal having an Aiolos deregulated cell.

Aiolos gene

Purified DNA including a sequence encoding an Ikaros protein.

Isolated antibody that binds to an Ikaros polypeptide

An Aiolos protein. The prior sentence is the abstract. Print as is and delete this message.

Ikaros: A T cell pathway regulatory gene

Transgenic cells, transgenic mice having an Ikaros transgene and methods for the use thereof.

Ikaros transgenic cells and mice

A monoclonal preparation of lymphocytes, their production and use.

Monoclonal lymphocytes and methods of use

A purified polypeptide having at least 85% sequence identity with an Ikaros polypeptide or exon.

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Lexington, MA, United States of America

Katia Georgopoulos