Université De Poitiers

Université D'angers

Bioalternatives Sas

Merck Sharp + Dohme Corp.

Katia Boniface

Robert A Kastelein

Rene De Waal Malefyt

Melanie A Kleinschek

Daniel J Cua

Sylvie Chevalier

Jean-Claude Lecron

Hughes Gascan

Hugues Gascan

Franck Morel

Francois-Xavier Bernard

Caroline Diveau

Kristian Sass Bak-Jensen

François-Xavier Bernard

Caroline Diveu

Edward Paul Bowman

Brent S Mckenzie

Kathy Lynn Miller

The invention disclosed herein relates to the field of epidermal repair and skin innate immunity. More particularly, the invention concerns the use of a mix of cytokines to inhibit keratinocyte differentiation, activate skin innate immunity, increase the expression of anti-microbial peptides, and improve epidermal repair. In particular, the invention concerns compositions comprising at least IL-17, TNF&#x3b1; and OSM that can be formulated for topical administration for cosmetic or dermatologic use.

Method for increasing the expression of anti-microbial peptides by keratinocytes comprising administering a composition comprising IL-17, TNF-alpha and OSM

The present invention relates to the field of epidermal repair. More particularly, the invention concerns the use of a molecule able to activate a heteromeric receptor comprising OSMR&#x3b2; as a subunit, for the preparation of a composition for activating in vitro and/or in vivo keratinocyte migration and/or the expression of anti-microbial peptides by the keratinocytes. In particular, the invention concerns the use of OSM and/or IL-17 and/or TNF&#x3b1; and/or IL-31, or agonists thereof, for the preparation of cosmetic or dermatologic compositions.

Compositions for enhancing keratinocyte migration and epidermal repair via a receptor containing OSMR&#x3b2; as a subunit, and applications thereof

Growing community of inventors

Mountain View, CA, United States of America

Katia Boniface