Novartis Ag

Glaxosmithkline Biologicals Sa

Irm LLC

Kathy Yue

Manmohan Singh

Yongkai Li

Xiaoyue Zhang

Alex Cortez

Tom Yao-Hsiang Wu

Timothy Z Hoffman

Yefen Zou

Jianfeng Pan

David Skibinski

Tom Yao Hsiang Wu

David A G Skibinski

David A G Skibinksi

David Ag Skibinski

Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.

Adsorption of immunopotentiators to insoluble metal salts

The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.

Compounds and compositions as TLR activity modulators

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Minneapolis, MN, United States of America

Kathy Yue