Enzon Labs Inc.

Enzon, Inc.

Genex Corporation

Kathy J Maugh

David M Anderson

Susan L Strausberg

Robert L Strausberg

Tena Wei

David R Filpula

Russ McCandliss

Recombinant production of bioadhesive precursor protein analogs is disclosed. The bioadhesive precursor protein analogs can be hydroxylated and used as an adhesive in wet environments.

Production of bioadhesive precursor protein analogs by genetically

Vectors are provided that are capable of expressing, in microbial transformants, a protein having the native amino acid sequence of a bioadhesive precursor protein of a marine animal selected from the group consisting of mussels, barnacles, and oysters. The bioadhesive precursor protein can be expressed in transformants, recovered and converted to a bioadhesive protein by hydroxylation.

Bioadhesive precursor protein expression vectors

Method of producing bioadhesive protein

Recombinant production of a bioadhesive precursor protein analog comprising three, five, ten, fifteen or twenty repeated decapeptides of the formula Ala-Lys-Pro-Ser-Tyr-Pro-Pro-Thr-Tyr-Lys is disclosed.

Escherichia coli expression vector encoding bioadhesive precursor

Bioadhesive coding sequences

Growing community of inventors

Walnut, CA, United States of America

Kathy J Maugh