Heptares Therapeutics Limited

Takeda Pharmaceutical Company Limited

Kathryn White

Miles Stuart Congreve

Giles Albert Brown

Michael Alistair O'Brien

David Livermore

Martin Teall

Stephen Mack

Anne Stephenson

Louise Dickson

Gemma Liwicki

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof wherein Z, R, R, R, R, Rand Rare as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy. The present invention further provides methods of treating at least one disease, disorder, or condition associated with the glutamatergic and GABAergic signalling pathways regulated in full or in part by metabotropic glutamate receptor 7 (mGluR7) by administering a compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject. The compound may be a selective agonist of mGluR7, which modulates the release of at least one neurotransmitter in the subject.

MGluR7 agonist compounds for treating mGluR7-regulated diseases, disorders, or conditions

The present invention provides muscarinic M4 receptor agonists of formula (I) and pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, Rand Rare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases such as schizophrenia, Alzheimer's disease and various cognitive disorders as well as in the treatment or alleviation of pain. 

Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor agonists

The present invention provides muscarinic Mreceptor agonists of formula (I) and pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, Rand Rare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases such as schizophrenia, Alzheimer's disease and various cognitive disorders as well as in the treatment or alleviation of pain. 

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Cambridge, United Kingdom

Kathryn White