New York University

Washington University

Kathryn J Moore

Bruce N Cronstein

Edward A Fisher

Carlos Fernandez-Hernando

Pallavi Chandra

Mireille Ouimet

Bhama Ramkhelawon

Katey J Rayner

Jennifer A Philips

Aranzazu Mediero-Munoz

Frederick Sheedy

Yajaira Suarez

Bruce Cronstein

Methods of using small molecule inhibitors of fatty acid oxidation (FAO) as antimicrobials against intracellular Mycobacteria are disclosed. FAO inhibitors including etomoxir, trimetazidine, oxfenicine perhexeline and/or can be used alone, or in combination with known as antimycobacterial agents against intracellular Mycobacteria.

Use of fatty acid oxidation inhibitors as antimicrobials

The invention provides methods and compositions for reducing or inhibiting osteolysis, bone resorption, osteoclast differentiation and stimulation and the loosening of medical prostheses by administering a compound or agent that inhibits the biological activity of an axon guidance protein. The compound or agent my inhibit transcription or translation of or bind to an axon guidance protein, such as, for instance, a netrin like netrin-1. Likewise, the compound or agent may inhibit transcription or translation of or bind to a receptor of an axon guidance protein, such as, for instance, a netrin receptor such as unc5b. In some instances, the compound or agent is an agonist of an adenosine Areceptor. The invention also extends to pharmaceutical compositions comprising such compounds and agents.

Methods for inhibiting osteolysis

The inhibition of miRNA miR-33 is shown to promote the polarization of macrophages from an M1 to an M2 phenotype. MiR-33 inhibitors are therefore useful for treating inflammation in subjects. Endogenous microRNAs can be silenced using antagomirs. The miR-33 inhibitor is preferably an antagomir having a single-stranded nucleic acid sequence that is complementary to at least 12 contiguous nucleotides in miR-33 and therefore forms a duplex with miR-33 under physiological conditions.

MiR-33 inhibitors and uses thereof to decrease inflammation

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Westfield, NJ, United States of America

Kathryn J Moore