The United States of America, as Represented by the Secretary, Department of Health and Human Services

Kathryn C Zoon

Renqiu Hu

Mark P Hayes

Raj K Puri

Syed R Husain

Joseph B Bekisz

Daniel S Green

Joseph B Beiksz

Methods and compositions are disclosed for treating a subject with a cancer. The compositions can include a chimeric molecule comprising an agent that specifically binds the interleukin 4 receptor (IL-4R) and a toxic moiety, an interferon alpha (IFN&#x3b1;), and an interferon gamma (IFN&#x3b3;). In some non-liming embodiments, the compositions can also include monocytes. The methods disclosed herein include administering a therapeutically effective amount of the compositions taught herein to a subject with cancer, thereby treating the cancer in the subject, wherein cells in the cancer express IL-4R. In some non-liming embodiments, the methods can also include administering monocytes.

Synergistic combination of IL-4, interferon gamma, and interferon alpha in treating ovarian cancer

Hybrid human interferon-&#x3b1; polypeptides, and the corresponding nucleic acid molecules, are disclosed. Pharmaceutical compositions comprising these peptides, and the use of these polypeptides to treat viral disease and regulate cell growth are also provided.

Interferon alpha hybrids

Hybrid human interferon-&agr; polypeptides, and the corresponding nucleic acid molecules, are disclosed. Pharmaceutical compositions comprising these peptides, and the use of these polypeptides to treat viral disease and regulate cell growth are also provided.

Interferon &agr; hybrids

Growing community of inventors

Kensington, MD, United States of America

Kathryn C Zoon