Bayer Aktiengesellschaft

Hoffmann-la Roche Inc.

Degussa Aktiengesellschaft

Creativequantum Gmbh

F. Hoffmann-la Roche Ag

Kathrin Junge

Matthias Beller

Michelangelo Scalone

Weiping Liu

Thomas Riermeier

Stephan Bachmann

Axel Monsees

Christoph Schotes

Harald Trauthwein

Marek Pawel Checinski

Jacob Schneekoenig

Thomas Leischner

Marcel Garbe

Pavel Ryabchuk

New iridium catalysts for enantioselective hydrogenation of 4-substituted 1,2-dihydroquinolines The invention relates to a process for preparing optically active 4-substituted 1,2,3,4-tetra hydroquinolines (la, lb) comprising enantioselective hydrogenation of the corresponding 4-substituted 1,2-dihydroquinolines in presence of a chiral iridium (P,N)-ligand catalyst.

Process comprising the use of new iridium catalysts for enantioselective hydrogenation of 4-substituted 1,2-dihydroquinolines

A process for catalyzed reaction of CO and Hinto methanol includes the step of reacting the CO and Hwith a catalyst comprising a transition metal and at least one Lewis basic ligand together with at least one nucleophilic promoter so as to produce the methanol as a product.

Process for producing methanol

The invention comprises novel chiral metal complex compounds of the formula  wherein M, PR, Rand Rare outlined in the description, its stereoisomers, in the form as a neutral complex or a complex cation with a suitable counter ion. The chiral metal complex compounds can be used in asymmetric reactions, particularly in asymmetric reductions of ketones, imines or oximes.

Chiral metal complex compounds

The invention relates to novel chiral ligands of formula (I), the production thereof and the use of the same in catalytic reactions.

Chiral ligands, transition metal complexes thereof, and the catalytic use of the same

Growing community of inventors

Rostock, Germany

Kathrin Junge