Abbvie Inc.

Kathreen A Gifford

Christopher Chumsae

Xiaobei Zeng

Kartik Subramanian

Diane D Dong

Wen Chung Lim

Hong Yang

Zehra Kaymakcalan

Natarajan Ramasubramanyan

Matthew Omon Herigstad

Lihua Yang

The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.

Cell culture methods to reduce acidic species

The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF&#x3b1; is detrimental, are also provided.

Low acidic species compositions and methods for producing and using the same

The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF&#x3b1; is detrimxental, are also provided.

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Marlborough, MA, United States of America

Kathreen A Gifford