Matrix Pharmaceutical, Inc.

Biomedicines, Inc.

Matrix Pharmaceuticals, Inc.

Kathleen V Roskos

Richard E Jones

Richard Maskiewicz

Keith Washco

George Trager

Methods and compositions are provided for the treatment of a host suffering from a cellular proliferative disease. In the subject methods, antiproliferative agents are administered in a substantially non-aqueous gel delivery vehicle comprising at least one polar organic solvent in combination with one or more thickening agents. The subject methods and compositions provide for the enhanced efficacy of regionally or locally administered antiproliferative proliferative agents.

Gel delivery vehicles for anticellular proliferative agents

An improved diluent for the preparation of cisplatin suspensions from a lyophilized powder is provided. The diluent contains a pharmaceutically acceptable nonionic surfactant, which improves the accuracy and homogeneity of the therapeutic formulation. The suspension may be used directly, or may be used in preparing gel formulations for direct injection into a neoplastic lesion or surrounding tissue.

Process and composition for therapeutic cisplatin (CDDP)

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Los Altos, CA, United States of America

Kathleen V Roskos