The Brigham and Women's Hospital, Inc.

Massachusetts Eye and Ear Infirmary

Kathleen Seyb

Gregory D Cuny

Lixin Qiao

Albert Edge

Marcie A Glicksman

Sang-Jun Jeon

This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

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Allston, MA, United States of America

Kathleen Seyb