Antriabio, Inc.

Eyetech Inc.

Kathleen M Campbell

Paul J Schmidt

Danny H Lewis

Pericles Calias

Gary Paul Cook

Perry Calias

Kenneth Hinds

Mary A Ganley

Gary P Cook

The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.

Site-specific insulin-polymer conjugates

Materials and methods for preparing protein-polymer conjugates

Formulations for controlled, sustained release of biologically active agents for the treatment of ocular disorders have been developed. These formulations are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. The microparticles are characterized by low burst levels and efficient drug loading and sustained release.

Controlled release microparticles

Growing community of inventors

Longmont, CO, United States of America

Kathleen M Campbell