Ortho Diagnostic Systems Inc.

Other

Ortho-clinical Diagnostics, Inc

Kathleen J Reis

Thomas M Setcavage

Rosemary K Chachowski

Linda J Davis

Milan Jorik

Donald M Davies

Walter Milchanoski

Diane E Bechtold

Thomas J Mercolino

Edward J Mazur

Simultaneous forward and reverse blood group testing is described using both a visual detection system and a fluorescent based labeling and detection system. Forward and reverse tests could be performed separately, but A and B agglutinates can be detected and discriminated simultaneously.

Simultaneous determination of forward and reverse ABO blood group

A vessel for conducting blood cell agglutination assays is disclosed. A barrier retains reactants in an upper chamber during incubation, then, in response to a force, permits reagents to enter a lower chamber containing a matrix for separating agglutination.

Agglutination reaction and separation vessel

Foil sealed cassette for agglutination reactions and liner therefor

The present invention provides a method and device for detecting the presence of binding ligands, especially blood group antigens or antibodies thereto, which utilize a matrix of substantially noncompressable microparticles, which matrix provides superior performance in allowing movement of nonagglutinated reactants, especially red blood cells, while constraining, preferably in a so-called 'band formation' agglutinated reactants, especially red blood cells. The device of the invention further comprises a chamber the transverse cross-sectional shape thereof being an ellipse, or preferably a flattened ellipse with two sides parallel to the longitudinal axis.

Column agglutination assay and device using biphasic centrifugation

The present invention provides a method and device for detecting the presence of binding ligands, especially blood group antigens or antibodies thereto, which utilize a matrix of substantially noncompressable microparticles, which matrix provides superior performance in allowing movement of nonagglutinated reactants, especially red blood cells, while constraining, preferably in a so-called 'band formation' agglutinated reactants, especially red blood cells.

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Milford, NJ, United States of America

Kathleen J Reis