University of Southern California

Other

Maret Corporation

Gaffney, Kevin J.

Rodgers, Kathleen, E.

Louie, Stan G.

Petasis, Nicos A.

Dizerega, Gere, S.

Kathleen Elizabeth Rodgers

Gere S DiZerega

Gere S diZerega

Gere Stodder Dizerega

Kevin J Gaffney

Stan G Louie

Nicos A Petasis

Maira Soto

Mark Salman Humayun

Mark S Humayun

Eve Kelland

Michael Weinberg

Brett Lund

Walid Fouad Ahmed Abdallah

Teshome L Aboye

Julio A Camarero Palao

Walid Fouad Abdallah

Disclosed herein are methods for increasing circulating mesenchymal stem cells by administering a compound having the general formula 1 as defined herein, or a pharmaceutically acceptable salt thereof.

Methods for increasing circulating mesenchymal stem cells

Methods for treating systemic lupus erythematosus (SLE) are disclosed, based on administering to a subject with SLE an amount effective to treat the subject of a polypeptide including antiogensin 1-7 (A(1-7)), Nle3A 1-7, or a compound according to general formula.

Methods for treating systemic lupus erythematosus

Disclosed herein are compositions including cyclodextrin and Nle3-A(1-7) [Asp-Arg-Me-Tyr-Ile-His-Pro (SEQ ID NO: 1)] and their use in treating various disorders.

Cyclodextrin-Nle3-A(1-7) compositions and their use

Described herein is a novel cyclotide able to activate the unique receptor of angiotensin-(1-7) (AT1-7), the MAS1 receptor. This cyclotide may be used in the treatment of cancer and myocardial infarction.

Proteolically resistant cyclotides with angiotensin 1-7 like activity

Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer. In particular, the invention provides compounds, methods and compositions for the treatment of metabolic diseases and disorders, such as diabetes mellitus, diabetes-related cardiovascular disorders, diabetes-related dermal ulcerations, diabetes related hypertension, and diabetes-related ophthalmic diseases.

Methods, compounds, and compositions for the treatment of angiotensin-related diseases

Described herein are compositions of alginate formulations that include water, divalent ions, and alginate cross-linked by the divalent ions, and their use for treating incisional wounds, such as intra-incisional application.

Use of alginate formulation for intraincisional drug delivery

This invention provides methods, compounds and compositions for the treatment of musculoskeletal disease, muscle dysfunction, muscle-wasting disease or disorder, including hereditary myopathy, neuromuscular disease, muscular dystrophy, muscular atrophy, drug-induced myopathy, and related disease, disorder or condition that causes a decrease in muscle strength, comprising the use of heterocyclic non-peptidic compounds that act as Mas agonists and/or mimics of angiotensin 1-7.

Methods, compounds, and compositions for the treatment of musculoskeletal diseases

Disclosed herein are methods for treating eye injuries by administering one or more angiotensin peptides to a subject with an eye injury.

Accelerated healing of eye injuries by angiotensin peptides

Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer.

The present invention provides methods for limiting development of skin wounds, and also for treatment of one or more of erythemas, blisters, rashes, pruritis, contact dermatitis, psoriasis, eczema, acne, and athlete's foot.

Methods for limiting development of a skin wound

The present invention provides methods for treating or limiting development of multiple sclerosis by administering angiotensin peptides to a subject with multiple sclerosis or at risk of developing multiple sclerosis.

Methods for treating multiple sclerosis

The present invention provides methods for treating a subject that has suffered combined exposure to total body ionizing irradiation and burns by administering a peptide of at least 5 amino acids of a peptide of SEQ ID NO:1 (Asp-Arg-Nle-Tyr-Ile-His-Pro), or a pharmaceutical salt thereof in an amount effective to treat the radiation effects and/or the burn.

Methods for treating combined radiation and thermal injury

The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers.

Growing community of inventors

Long Beach, CA, United States of America

Kathleen Elizabeth Rodgers