Merck + Co., Inc.

Kathleen A Sullivan

Carina P Tan

Margaret A Cascieri

Leonardus H T Van Der Ploeg

Kevin R Lynch

Andrew D Howard

Roy G Smith

Michael R Tota

Lin-Lin Shiao

Diana Benincasa

Lyndon J Mitnaul

Methods of identifying inhibitors of the fusion of two types of cells, particularly when fusion is mediated by the interaction of a viral protein and such cellular proteins as CD4 and chemokine receptors, are disclosed. The methods are suitable for identifying substances that are useful for the treatment and prevention of viral diseases. Particularly preferred methods are useful for the identification of inhibitors of HIV-1 infection.

Cell fusion assays using fluorescence resonance energy transfer

A new galanin receptor, GALR2, is described. Also provided are nucleic acids encoding same and various assays to identify ligands particular to said receptor. Ligands so identified are useful for the treatment of obesity, treatment of pain, and treatment of cognitive disorders.

Galanin receptor (GALR2) binding assay

A new galanin receptor, GALR3, is described. Also provided are nucleic acids encoding same and various assays to identify ligands particular to said receptor. Ligands so identified are useful for the treatment of obesity, treatment of pain, and treatment of cognitive disorders.

Nucleotide encoding human galanin receptor 3 (GALR3)

Nucleic acid encoding rat galanin receptor (GALR2)

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Springfield, NJ, United States of America

Kathleen A Sullivan