Teikoku Pharma Usa, Inc.

Diametrics Medical Limited

Kathleen A Eischen

Carter R Anderson

Russell L Morris

James W Kenney

A wearable iontophoresis device for the prolonged delivery of a positively charged pharmaceutical species from a salt formulation is disclosed that includes a readily oxidizable metal-based sacrificial anode in the form of a generally planar layer having a connecting area that has a width that is sufficient to insure complete consumption of the oxidizable metal wherein the anode is configured to have a minimum operating life of at least 6 hours under skin-safe conditions, and a drug delivery gel pad in electrical contact with said anode for accommodating a gel containing a positively charged pharmaceutical species in salt form formulated for transdermal delivery.

Sacrificial electrode design and delivery species suitable for prolonged iontophoresis application periods

A disposable, vented capillary draw device is described that is also capable of use for the syringe pressurized dispensing of liquid benignly drawn. The system includes a vented capillary collection tube for drawing liquid samples by capillary rise in a bubble-free manner. A reversible, positive vent shut-off is provided to help contain the drawn material in the capillary. A reciprocating, loose fitting, syringe plunger arrangement is also provided attached to and operable in the capillary tube. Initial axial displacement of the plunger in the capillary toward the open end is used to initially operate the vent seal or positive vent shut-off device to close the vent and, upon further advancement of the plunger, the plunger forces the liquid material back out of the draw tube.

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Saint Paul, MN, United States of America

Kathleen A Eischen