Bristol-Myers Squibb Compnay

Bristol-Myers Squibb

Bristol-Meyers Squibb

Katherine S Takaki

Graham Johnson

Daniel J Keavy

Brett T Watson

Joseph P Yevich

Michael Frederick Parker

James R Epperson

Stephen R Bertenshaw

Ronald J Mattson

John D Catt

George N Karageorge

Jie Chen

Graham S Poindexter

Karen L Leboulluec

Li-Qiang Sun

Guanglin Luo

Pierre Dextraze

Marc A Bruce

Derek John Denhart

Marco Dodier

Li-Quang Sun

Astrid A Ortiz

Novel benzoxazole derivatives which have a binding affinity for the human melatonin receptor and, therefore, are useful as melatonergic agents.

Benzoxazole derivatives as novel melatonergic agents

Novel benzofuran and dihydrobenzofuran derivatives which have a binding affinity for the human melatonin receptor and, therefore, are useful as melatonergic agents.

Arylalkylbenzofuran derivatives as melatonergic agents

There is provided a novel series of cis cyclopropane compounds of Formula I

Heterocyclic cis cyclopropane derivatives as melatonergic agents

There is provided a novel series of heterocyclic aminopyrrolidine compounds of Formula I

Heterocyclic aminopyrrolidine derivatives as melatonergic agents

Novel derivatives of benzopyran are provided which are useful as melatonergic agents.

Benzopyran derivatives as melatonergic agents

There is provided novel spirocyclopropyl fluorene derivatives having the general Formula I ##STR1## wherein R, R.sup.1 and X are as defined herein which are useful as melatonergic agents.

Spirocyclopropyl fluorenes as melatonergic agents

Novel derivatives of benzodioxa alkylene ethers are provided which are useful as melatonergic agents.

Benzodioxa alkylene ethers as melatonergic agents

Novel polycyclic ethyl alkylamides of formula I are active as melatonergic agents. ##STR1## wherein Z=CH (when a double bond is present) or (CH.sub.2).sub.n, wherein n is 1-4;

Polycyclic ethyl alkylamide melatonergic agents

A series of pyridinyl tri-substituted benzamide derivatives of general structure ##STR1## wherein the symbols R.sup.1, R.sup.2, X and n are described in detail in the specification, are useful as anticonvulsants agents.

Anticonvulsant pyridinyl benzamide derivatives

Novel derivatives of benzofuran and dihydrobenzofuran are provided which are useful as melatonergic agents.

Benzofuran and dihydrobenzofuran melatonergic agents

Novel substituted fluorene compunds of Formula I are active as melatonergic agents: ##STR1## wherein: X=H, halogen, OH or OZ;

Ethylamido fluorenes and improved method of making same

Novel substituted carbazole compounds of Formula I are active as melatonergic agents: ##STR1## wherein: R.sub.1 is C(O)R.sub.3 or SO.sub.2 R.sub.4 ;

Ethylamino carbazole melatonergic agents

New melatonergic agents are phenyl alkanyl or phenyl alkyl substituted carboxamides and ureas of Formula I: ##STR1## wherein: R.sub.1 =C.sub.1-3 alkyl, allyl, C.sub.3-6 cycloalkyl substituted C.sub.1-4 alkyl;

Melatonergic agents

Certain tetralinyl- and indanyl-ethylamides are useful central nervous system agents.

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Middletown, CT, United States of America

Katherine S Takaki