Glaxosmithkline Intellectual Property Development Limited

Fimbrion Therapeutics, Inc.

Katherine Louisa Widdowson

James Walter Janetka

Michael Joseph Bishop

Eugene L Stewart

Laurel Kathryn McGrane

Laurel Kathryn Mcgrane

Vincent J Colandrea

Iulia Strambeanu

Yuehu Li

Disclosed herein are new O-biphenyl- and O-phenylheteroarylmannoside compounds and compositions and their application as pharmaceuticals for use in the treatment of human disease. Methods of inhibition of FimH activity in human subjects are also provided for the treatment of diseases such as urinary tract infection.

Substituted biphenyl or phenylheteroaryl-mannosides as antagonists of FimH

Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in human subjects are also provided for the treatment diseases such as urinary tract infection.

Compounds

Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).

C-mannoside compounds useful for the treatment of urinary tract infections

The present invention relates to methods for treatinginfection which comprises administering to a subject in need thereof novel Tricyclic nitrogen containing compounds and corresponding pharmaceutical compositions as described herein. 

Method for treating gonorrhea with (2R)-2-({4-[(3,4-dihydro-2H-pyrano[2,3-C]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2A,5,8A-triazaacenaphthylene-3,8-dione

Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment diseases such as urinary tract infection.

The present invention relates to methods for treatinginfection which comprises administering to a subject in need thereof novel 1,2-dihydro-2a,5,8a-triazaacenaphthylene-3,8-dione compounds: or

Growing community of inventors

San Diego, CA, United States of America

Katherine Louisa Widdowson