Astrazeneca Ab

Katherine Knappenberger

Suzanne J Suchard

Marc Chapdelaine

Rebecca Urbanek

Gary Steelman

Linda Sygowski

Chris Allan Veale

Substituted naphthalenediones in accord with structural diagram (I): compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In compounds of the invention, wherein: Qat each occurrence is independently selected from hydrogen, hydroxy, halogen, C(O)O(C-C) alkyl and C(O)phenyl, and Qis selected from hydrogen, halogen, O&#x2014;(C-C)alkyl, O&#x2014;(C-C)alkenyl, phenyl, indolyl and naphthyl, where phenyl may be mono- or di-substituted with NOor halogen, and indolyl may be substituted with (C-C)alkyl or phenyl

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Wilmington, DE, United States of America

Katherine Knappenberger