Nkarta, Inc.

Katherine Jamboretz

Alexandra Leida Liana Lazetic

Ivan Ho Chan

James Barnaby Trager

Chao Guo

Several embodiments of the methods and compositions disclosed herein relate to immune cells that are engineered to express chimeric antigen receptors (CAR) and/or genetically modified to reduce potential side effects of cellular immunotherapy. Several embodiments relate to genetic modifications to the immune cells, such as Natural Killer (NK) cells, to reduce, substantially, reduce, or eliminate expression of a marker by the immune cells that would otherwise cause them to be self-targeted by the CAR. In several embodiments, the CAR targets CD70, and in some embodiments is used for renal cell carcinoma immunotherapy.

Growing community of inventors

San Francisco, CA, United States of America

Katherine Jamboretz