Duke University

Katherine J Franz

Dennis J Thiele

Marian Helsel

Richard Festa

Katie L Ciesienski

Marina G D Leed

Daniel George

Drew Folk

Patrick C Seed

Mark Sleeper

Subha Bakthavatsalam

David M Besse

Filip Kielar

Tian Zhang

Louise K Charkoudian

The present disclosure provides prochelators as targeted prodrugs for cancer, such as prostate cancer, and methods of making and using the same.

Prochelators as targeted prodrugs for prostate cancer and methods of making and using same

The present disclosure provides antibacterial prodrugs and methods of making and using the same.

Antimicrobial prochelators to target drug-resistant bacteria and methods of making and using the same

The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.

Prochelators as broad-spectrum antimicrobial agents and methods of use

The present invention provides compounds of Formula I: along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer.

Photolabile caged transition metal complexes and methods of using the same

Prochelator compounds of Formula I or Formula II: are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same.

Prochelators useful for inhibiting metal-associated toxicity

Molecular probes are provided for use in fluorescence microscopy procedures for monitoring beta-secretase enzyme (BACE) activity in living cells and organisms. The probes may be useful for monitoring Alzheimer's Disease-associated BACE in living cells. By fluorescing when hydrolyzed by BACE, the probes can allow for real-time spatial and temporal assessment of enzymatic activity without the need for mutated cell lines or antibodies. The molecular probes may also be used to screen libraries of potential BACE inhibitors or evaluate how external stimuli affect BACE activity.

Compositions and methods for imaging beta-secretase activity in living cells and organisms

Prochelator compounds of Formula (I) or Formula (II) are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same.

The present invention provides compounds of Formula I along with compositions containing the same and methods of use thereof in treating oxidative stress. 

Prochelators for inhibiting metal-promoted oxidative stress

The present invention provides compounds of Formula I: (I) along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer. 

The present invention provides compounds of Formula (I): along with compositions containing the same and methods of use thereof in treating oxidative stress.

Growing community of inventors

Durham, NC, United States of America

Katherine J Franz