Pfizer Corporation

Katherine E Brighty

Paul R McGuirk

John Adams Lowe, Iii

Anthony Marfat

Takushi Kaneko

Robert G Linde, Ii

John P O'Donnell

Yong-Jin Wu

Matthew Merrill Hayward

Bingwei Vera Yang

Martin R Jefson

Tamim F Braish

Hiroko Masamune

Wei-Guo Su

Subramanian Sam Guhan

David L Lindner

Dale G McLeod

Robert Gerald Linde, Iii

Ellen Lester McCormick

Dale M McLeod

Orally bioavailable prodrugs of sulopenem, e.g., and solvates and hydrates thereof, preparation thereof, formulation thereof, and use to treat and prevent infection in mammals such as humans. This abstract is not limiting to the invention.

Penem prodrugs

Hygromycin derivatives

This invention relates to compounds of the formula

C-4 substituted macrolide antibiotics

This invention relates to certain azabicyclo hexane intermediates and processes for making and using the azabicyclo hexane intermediates. The intermediates are useful in the synthesis of quinolone antibacterial agents.

Aza bicyclo[3,1,0]hexane intermediates useful in the synthesis of

Quinolone carboxylic acids 7 -substituted by azabicyclo groups have antibacterial activity.

3-aza-bicyclo[3.1.0]hexanes which are intermediates for anti-bacterial

Quinolone carboxylic acids 7-substituted by azabicyclo groups have antibacterial activity.

Azatricyclo carboxylic acids useful as anti-bacterial agents

Anti-bacterial azabicyclo quinolone carboxylic acids

Thiazolyl and oxazolyl [5,4-c] piperidyl-substituted quinolone-carboxylic acids and related analogs thereof having antibacterial properties are disclosed.

Thiazolyl and oxazolyl[5,4-c]piperidyl-substituted quinolone-carboxylic

Azabicyclo quinolone and naphthyridinone carboxylic acids

1-Substituted-6-fluoro-7-heterocyclic-1,4-dihydroquino-1-(or dihydronaphthyridin)-4-one carboxylic acids have antibacterial properties. The 7-heterocyclic group is a bicyclic group, one of the rings of which is saturated and the other ring of which is unsaturated.

Heterocycylic-substituted quinoline-carboxylic acids

An efficient process for converting readily available 4-acetoxy-2-azetidinones to allyl 2-thioxopenam-3-carboxylates, intermediates useful for the synthesis of penem antibiotics.

Process for penem derivatives

A process for the synthesis of penems from azetidinones via 1-aza-4,5-dithiabicyclo[4.2.0]oct-2-en-8-one-2-carboxylate esters.

Process for the synthesis of penems

1-aza-4,5-dithiabicyclo [4.2.0] oct-2-en-8-one-2 carboxylate ester intermediates useful for the synthesis of penems.

Growing community of inventors

Groton, CT, United States of America

Katherine E Brighty