Wisconsin Alumni Research Foundation

University of California

Katherine Ann Hurley

Douglas Benjamin Weibel

Katherine Cassidy Faulkner

Jared T Shaw

Ye Jin Eun

Jared T Moore

Marie Hazel Foss

Molly R Fensterwald

Described herein are antimicrobial compounds identified via a high-throughput inhibitor screen of the in vitro activity of MipZ, which is an ATPase that regulates division site placement in. The compounds and their analogs are active against bacterial membranes and thus represent a novel class of antimicrobial compounds. The antimicrobial compounds are effective against both actively growing bacterial cells as well as bacterial cells in the stationary phase. The antimicrobial compounds are also effective against bacteria in biofilms.

Antimicrobial compounds, compositions and methods of use thereof

The present invention provides N-benzyl-3-sulfonamidopyrrolidines and related compounds, as well as pharmaceutical compositions and sanitizing compositions containing the same. The compounds and compositions are useful as antibiotic agents. Methods for making and using the compounds and compositions are also described.

Inhibitors of bacterial DNA gyrase with efficacy against gram-negative bacteria

Described herein are antimicrobial compounds identified via a high-throughput screen to identify compounds that produce anucleate cells inafter cell division occurs. Compound 1 (5-nonyloxytryptamine) and its analogs are small molecule inhibitors of the nucleoid occlusion system and/or proteins that are responsible for maintaining the structure of the chromosome. The antimicrobial compounds are useful to treat bacterial infections as well as to inhibit bacterial growth.

Growing community of inventors

Madison, WI, United States of America

Katherine Ann Hurley