Purdue Research Foundation

Symic Ip, LLC

Symic Holdings, Inc.

Symic Biomedical, Inc.

Katherine Allison Stuart

John Eric Paderi

Alyssa Panitch

Kinam Park

Steve Higbee

Shaili Sharma

Nelda Marie Vazquez-Portalatin

Glenn D Prestwich

Harsha Kabra

Elvis Ikwa

Provided herein are synthetic bioconjugates comprising collagen-binding peptides covalently bound to chemically modified glycan backbones, compositions containing the same, and uses thereof.

Bioconjugates with chemically modified backbones

This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

Collagen-binding synthetic peptidoglycans, preparation, and methods of use

This disclosure provides extracellular matrix-binding synthetic peptidoglycans comprised of one or more synthetic peptides conjugated to a glycan and methods of their use.

Extracellular matrix-binding synthetic peptidoglycans

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San Francisco, CA, United States of America

Katherine Allison Stuart