Nereus Pharmaceuticals, Inc.

Other

Katherine A McArthur

Barbara Christine Potts

Rama Manam

Ta-Hsiang Chao

Venkat Rami Reddy Macherla

Saskia Theodora Cornelia Neuteboom

Venkata Rami Reddy Macherla

Taotao Ling

Kin S Lam

Benjamin Nicholson

Scott Sherman Mitchell

Venkat Macherla

Ram Rao Manam

Saskia Neuteboom

Cheryl L Billstrom

Disclosed herein are compounds of Formula (I) that include a sulfonate ester, ester or ether group. Compounds of Formula (I) can be included in pharmaceutical compositions, and can be used to treating and/or ameliorating a disease or condition, such as cancer, a microbial disease and/or inflammation.

Proteasome inhibitors

The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V). 

Total synthesis of salinosporamide A and analogs thereof

Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

[3.2.0] Heterocyclic compounds and methods of using the same

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La Mesa, CA, United States of America

Katherine A McArthur