Endeavor Pharmaceuticals

Katherin M Schlipp

Robert R Whittle

Frederick D Sancilio

Thomas W Leonard

Edward N Hill

Dean G Shirazi

A composition of matter is provided having a mixture of active estrogenic compounds. The mixture is present in chemically pure form. The mixture includes salts of conjugated estrone, conjugated equilin, conjugated &#x394;-dehydroestrone, conjugated 17&#x3b1;-estradiol, conjugated 17&#x3b1;-dihydroequilin, conjugated 17&#x3b2;-dihydroequilin, conjugated 17&#x3b2;-estradiol, conjugated equilenin, conjugated 17&#x3b1;-dihydroequilenin, and conjugated 17&#x3b2;-dihydroequilenin. The mixture also contains the same essential estrogenic compounds present in naturally derived equine conjugated estrogens. Drug products including the composition of matter are also provided, as are methods of using these drug products to treat mammals in need of treatment. Methods of analyzing mixtures containing conjugated estrogens are also provided.

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Wilmington, NC, United States of America

Katherin M Schlipp