Novartis Vaccines & Diagnostics, Gmbh

Chiron Corporation

Kathelyn S Steimer

Philip J Barr

Dino Dina

Paul A Luciw

Carlos George-Nascimento

Martha Truett

Deborah Lynn Parkes

Ray Sanchez Pescador

Rob Hallewell

Michael Houghton

Amy J Weiner

Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.

Purified pol DNA, a recombinant DNA construct for expression of HIV pol polypeptide sequences and a cell containing such construct

Method for expressing HIV polypeptides

Recombinant DNA construct for HIV envelope polypeptides and polypeptides produced thereby

Human immunodeficiency virus (HIV) nucleotide sequences

HIV immunoassays using gag polypeptides

The present invention is directed to extracorporeal cell systems infected with hepatitis C virus (HCV). The present invention also relates to products of such cell systems and their use as vaccines and in immunoassays. Methods whereby HCV-infected extracorporeal cell systems are constructed are included, and various immunoassays to detect HCV antibodies are also presented. The HCV-infected cell systems can be used to screen putative antiviral agents.

Hepatitis C virus infected cell systems

Growing community of inventors

Benicia, CA, United States of America

Kathelyn S Steimer