Biomay Ag

Katharina Blatt

Rudolf Valenta

Peter Valent

Margarete Focke-Tejkl

Birgit Linhart

Dietrich Kraft

Susanne Vrtala

Susanne Spitzauer

Ines Swoboda

Angela Neubauer

Raffaela Campana

Anna Gieras

The present invention relates to a method for identifying hypoallergenic polypeptides and to a corresponding screening method. The invention further relates to hypoallergenic polypeptides identified by the method of the invention and to the prophylactic and therapeutic use of these polypeptides.

Hypoallergenic hybrid polypeptides for the treatment of allergy

Hypoallergenic mosaic antigens assembled from naturally-occurring allergens are disclosed herein. Also disclosed are methods of making such hypoallergenic mosaic antigens, particularly those derived from plant allergens such as timothy grass pollen (Phl p 1 and Phl p 2) and birch pollen (Bet v 1). In a particularly preferred embodiment, the method of making the hypoallergenic mosaic antigen involves the steps of (a) cleaving a naturally-occurring allergen into at least two, preferably at least three non-overlapping peptide fragments and (b) recombining the peptide fragments such that the mosaic antigen includes all or substantially all of the amino acids of the original naturally-occurring allergen, though in a different order.

Hypallergenic mosaic antigens and methods of making same

Growing community of inventors

Gross-Enzersdorf, Austria

Katharina Blatt