Quonova, LLC

4Sc Ag

Katharina Aulinger-Fuchs

Bernd Kramer

Andreas Wuzik

Wael Saeb

Astrid Gotschlich

Martin Lang

Udo Sinks

Aldo Ammendola

Johann Leban

Stefan Tasler

Roland Baumgartner

The present invention relates to the use of compounds of the general Formula (XIII): 

Modulation of pathogenicity

The present invention relates to the use of compounds of the general Formula (I): wherein in Formula (I),

The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.

Method of identifying inhibitors of DHODH

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Neuried, Germany

Katharina Aulinger-Fuchs