King Fahd University of Petroleum and Minerals

Katharigatta N Venugopala

Pran Kishore Deb

Mohamed A Morsy

Bandar Aldhubiab

Sandeep Chandrashekharappa

Mahesh Attimarad

Nagaraja Sreeharsha

Anroop B Nair

Melendran Pillay

Rashmi Venugopala

Vinuta Kamat

Osama I Alwassil

Boja Poojary

Vijaykumar Uppar

Rangappa Santosh

Manohar S Kugaji

Vijay M Kumbar

Sheena Shashikanth

Basavaraj Padmashali

Raghu Prasad Mailavaram

Christophe Tratrat

Nefisath P

Jagadeesh Prasad Dasappa

Shashiprabha S

Amit Kumar

Nizar A Al-Shar'i

Mahmoud Kandeel

Keshab M Bairagi

Susanta K Nayak

Viresh Mohanlall

Bapi Gorain

Swastika Ganguly

Pramod Dhanaji Patil

Sandeep Chandrashekarappa

Annie Lee Pei Wen

Goh Hui Shan

Dhakshanamurthy Thirumalai

Madhusudana Reddy Muthukurpalya Bhojegowd

Sonia Kundu

Ramasamy Durai

Melandran Pillay

Jamie Kow Kean Hing

Lim Tse Mun

Bandar Adlhubiab

Suvadra Das

Praveen B Managutti

Aalok Basu

Priya R Kadam

Yadav D Bodke

Gabriella Marucci

Buccioni Michela

Teeka Sathiesh Roopashree

Wafa Hourani

Partha Roy

Basavraj Padmashali

Compounds for treating a microbial and/or bacterial infection and, particularly, to compounds of formula 4 as identified below that are 5-(substitutedphenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-microbial or anti-bacterial agents, with the substituents defined as stated herein.

5-(substitutedphenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues as antibacterial agents

Novel 1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide derivatives compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide derivatives compounds, are useful as anti-tubercular agents.

1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide as anti-tubercular agents

Novel 2-(substituted benzyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones and 4-fluoro-N-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)benzamide compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 2-(substituted benzyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones and 4-fluoro-N-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)benzamide compounds, identified as COX-2 inhibitors, are useful as anti-inflammatory and pain agents.

Selective COX-2 inhibition of 2-(substituted benzyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones and 4-fluoro-n-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)benzamide as anti-inflammatory agents

Compounds for treating a microbial and/or bacterial infection and, particularly, to compounds that are 5-(substituted phenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-microbial or anti-bacterial agents. The compounds having the formula 4:

Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are (E)-1-(2-(4-substitutedphenyl)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridinium bromides and their use as anti-tubercular agents.

(e)-1-(2-(4-substitutedphenyl)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridinium bromides as antitubercular agents

Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are 4-cyano-1-(2-oxo-2-(substituted phenyl)ethyl)pyridin-1-ium bromides and their use as anti-tubercular agents.

4-cyano-1-(2-oxo-2-(substituted phenyl) ethyl) pyridin-1-ium bromides as anti-tubercular agents

Methods of treating cancer in a patient by administering ethyl-1-(substituted benzoyl)-5-methylpyrrolo[1,2-a]quinoline-3-carboxylates to a patient in need thereof.

Ethyl-1-(substitutedbenzoyl)-5-methylpyrrolo[1,2-a]quinoline-3-carboxylates as anticancer agents

Compounds for treating an inflammatory disease, disorder, or condition and, particularly, to compounds that are 5-(substitutedphenyl)-7-imino-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-inflammatory agents.

5-(Substitutedphenyl)-7-Imino-7,8-Dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues as anti-inflammatory agents

Novel arylhydrazones derivatives, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The arylhydrazones derivative compounds are useful as anti-tubercular agents.

(E)-2-(3-Cyano-4-isobutoxyphenyl)-N'-(substituted benzylidene)-4-methylthiazole-5-carbohydrazides as anti-tubercular agents

(E)-2-(3-cyano-4-isobutoxyphenyl)-n'-(substituted benzylidene)-4-methylthiazole-5-carbohydrazides as anti-tubercular agents

7-Imino-5-(1H-indol-3-yl)-1,3-substituted-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The present compounds, identified as COX-2 inhibitors, are useful as anti-inflammatory agents.

7-Imino-5-(1H-indol-3-yl)-1,3-substituted-7,8-dihdropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione as anti-inflammatory agents

Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are substituted 1,3,4-oxadiazole derivatives and their use as anti-tubercular agents are provided.

Substituted 1,3,4-oxadiazole derivatives as anti-tubercular agents

Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are (6-methyl-4-substitutedphenyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanones and their use as anti-tubercular agents are provided.

(6-methyl-4-substitutedphenyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanones as antitubercular agents

Compounds for treating a microbial infection and/or tuberculosis and, particularly, antimicrobial and/or antitubercular compounds that are 3-cyano 4,5-diphenyl furan-2-carboxamides and their use as antimicrobial and/or antitubercular agents are provided.

3-cyano 4,5-diphenyl furan-2-carboxamides as antitubercular agents

Novel 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7-tricarboxylates compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7-tricarboxylates compounds, identified as adenosine Areceptor (AAR) modulators, are useful as anti-inflammation, anticancer and/or anti-ischemic agents, and as agents for treating other adenosine overexpression related conditions including rheumatoid arthritis, psoriasis and fatty liver diseases, inflammation, pain, and number of pathological conditions of the central and peripheral nervous systems.

7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7 tricarboxylates as adenosine receptor active compounds

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Al-Ahsa, Saudi Arabia

Katharigatta N Venugopala