Incuron, LLC

Health Research, Inc.

Panacela Labs, Inc.

Roswell Park Cancer Institute

Katerina Gurova

Andrei V Gudkov

John Alan Tucker

Catherine Burkhart

Sergey Sviridov

Andrei Purmal

Leonid Brodsky

Natalya Narizhneva

Nickolay Neznanov

The present invention relates to, inter alia, measuring of at least one component of the facilitates chromatin transcription complex (FACT) for evaluating a tumor, including, for example, determining the aggressiveness of a tumor and directing treatment.

Use of facilitates chromatin transcription complex (FACT) in cancer

Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include cancers, inflammatory diseases and conditions, and immunodeficiency diseases. (I), (II).

Carbazole compounds and therapeutic uses of the compounds

The present invention relates to the treatment of breast cancer which is estrogen receptor positive (ER) and/or human epidermal growth factor receptor 2 positive (HER2) and/or progesterone receptor positive (PR) and/or facilitates chromatin transcription positive (FACT+) with a curaxin, including curaxin 137. The present invention also pertains to a method of identifying a subject who has a breast cancer tumor and is likely to respond to treatment with a curaxin.

Curaxins for use in treating carcinogen-induced cancer

Provided is a method of inhibiting growth of androgen receptor positive cancer cells. The method entails administering to an individual diagnosed with or suspected of having an androgen receptor positive cancer and administering to the individual a composition containing a compound that can inhibit the growth of the androgen receptor positive cancer.

Method for treating androgen receptor positive cancers

Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include cancers, inflammatory diseases and conditions, and immunodeficiency diseases. 

Provided herein is a method for inducing cell death by inducing heat shock response in a cell in combination with inhibiting adaptive heat shock response. Also provided are methods for preventing cancer, treating intracellular parasite infections, and inflammation-associated conditions.

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Orchard Park, NY, United States of America

Katerina Gurova