Richter Gedeon Vegyeszeti Gyar Rt

Richter Gedeon Nyrt.

Richter Gedeon Vegeyszeti Gyar Rt.

Katalin Nogradi

Laszlo Czibula

Janos Galambos

Eva Againe Csongor

Janos Kreidl

Ferenc Sebok

Balint Juhasz

Csaba Szantay

Bela Stefko

Istvan Gyertyan

Katalin Saghy

Maria Farkas Nee Kirjak

Gyorgy Visky

Ida Deutsch Nee Juhasz

Istvan Vago

Bela Benke

Zsuzsanna Aracs Nee Tischler

Lajos Szabo

Bela Kiss

Gyorgy Kalaus

Lajos Dancsi

Istvan Laszlovszky

Judit Laszy

Karola Jovanovics

Andras Nemes

Csaba Lorincz

Lajos Kovacs

Katalin Honty

Ferenc Drexler

Eszter Dezseri

Janos Sapi

Istvan Hegedus

Judit M Meszaros Nee Brill

Maria Stiller

Monika Vastag

Béla Kiss

Bela Szarvady

Amrita Agnes Bobok

István Laszlovszky

Judit Brill, Deceased

Maria F Nee Kirjak

Ida D Nee Juhasz

Judit Meszaros Nee Brill, Deceased

Kalmam Gaf

Katalin Horvath Nee Berki

Kalman Graf

Lajos Szaho

Ottilia Elekes

János Galambos

Bálint Juhasz

Lászl Czibula

István Vago

ÉVa ÁGainÉ Csongor

István Gyertyan

Eva Againe' Csongor

György Miklos Keseru

The invention relates to novel trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate and a process for the preparation of the trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate, said process comprising the steps a) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)amino]-cyclohexyl}-acetic acid ester with sodium borohydride and aluminum trichloride to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethanol; b) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]cyclohexyl}-ethanol obtained with methanesulfonic acid chloride in the presence of an acid binding agent to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethyl methanesulfonate; c) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethyl methanesulfonate obtained with 2,3-dichlorophenyl-piperazine in the presence of an acid binding agent to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-carbamic acid tert-butylester;d) heating trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-carbamic acid tert-butylester obtained to a temperature between 40-100&#xb0; C. in a mixture of aqueous hydrochloric acid/methanol to give trans N-{4-{2-[4-(2,3-dichlorophenyl)piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate.

Piperazine salt and a process for the preparation thereof

The invention relates to a new process for the preparation of compounds of general formula (I) wherein Rand Rrepresent independently hydrogen or 

Process for the preparation of piperazine compounds and hydrochloride salts thereof

The invention relates to a process for the preparation of the trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl}-cyclohexyl}-carbamide derivatives of general formula (I) by reacting the compound of formula (III) with a carbamoylchloride of general formula (II) which comprises carrying out the reaction in a mixture of a solvent and concentrated aqueous solution of an alkali hydroxide at a temperature between 40-100&#xb0; C. in the presence of a phase transfer catalyst, separating the phases and washing the organic layer then removing the solvent and drying the compound of formula (I) obtained until its weight is constant.

Process for the preparation of piperazine derivatives

Provided herein are Thieno[2,3-b]pyridine compounds with mGluR activity. Also provided herein are processes and intermediates for the preparation of the Thieno[2,3-b]pyridine compounds, pharmaceutical compositions containing these compounds, and the use of these compounds in treatment, therapy, and/or prevention of conditions which require modulation of mGluR1 and mGluR5 receptors.

Thieno [2,3-b] pyridine compounds with mGluR activity

The present invention relates to new D3 and D2 dopamine receptor subtype preferring ligands of formula (I): wherein Rand Rrepresent independently a substituent selected from hydrogen, alkyl, aryl, cycloalkyl, aroyl, or Rand Rmay form a heterocyclic ring with the adjacent nitrogen atom; X represents an oxygen or sulphur atom; n is an integer of from 1 to 2, and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates thereof, to the processes for producing the same, to pharmaceutical compositions containing the same and to their use in therapy and/or prevention of a condition which requires modulation of dopamine receptors.

(Thio) carbamoyl-cyclohexane derivatives as D3/D2 receptor antagonists

Process for the preparation of

The present invention relates to racemic or optically active cis octahydro-indolo [2,3-a] quinolizine diester derivatives.

Process for preparing the octahydro-indolo[2,3-a] quinolizine diester

New intermediate compounds are disclosed of the formula I, ##STR1## wherein R.sub.1 and R.sub.2 are independently alkyl having 1 to 4 carbon atoms, or acid-addition salts thereof of formula Ib, ##STR2## wherein X represents an acid residue, and a process for the preparation of the intermediate compounds.

Racemic and optically active octahydro-indolo(2,3-a) tetrahydropyranyl

A process for the preparation of alkaloids of the leurosine type having the formula I ##STR1## and the acid addition salts thereof. In the formula I R is hydrogen or methyl. The compounds prepared according to the invention are known compounds showing cytostatic activity.

Process for the preparation of alkaloids of the leurosine type

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Budapest, Hungary

Katalin Nogradi